ArticleSystematic biology2022
Nucleotide Substitutions during Speciation may Explain Substitution Rate Variation.
Article in Systematic biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Pan-mitogenome in Dipterocarpoideae: mitochondrial plastid DNAs and repeats shape the dynamic evolution of mitogenomes.BMC plant biology · 2025Article
- NGATHA carpel development genes evolved in the common ancestor of seed plants.The Plant journal : for cell and molecular biology · 2025Article
- Mutation Rate Variation and Other Challenges in 2-LTR Dating of Primate Endogenous Retrovirus Integrations.Journal of molecular evolution · 2025Review
- Combining Molecular, Macroevolutionary, and Macroecological Perspectives on the Generation of Diversity.Cold Spring Harbor perspectives in biology · 2024Review
- Evaluating the Accuracy of Methods for Detecting Correlated Rates of Molecular and Morphological Evolution.Systematic biology · 2023Article
- Investigating the reliability of molecular estimates of evolutionary time when substitution rates and speciation rates vary.BMC ecology and evolution · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
Although molecular mechanisms associated with the generation of mutations are highly conserved across taxa, there is widespread variation in mutation rates between evolutionary lineages. When phylogenies are reconstructed based on nucleotide sequences, such variation is typically accounted for by the assumption of a relaxed molecular clock, which is a statistical distribution of mutation rates without much underlying biological mechanism. Here, we propose that variation in accumulated mutations may be partly explained by an elevated mutation rate during speciation. Using simulations, we show how shifting mutations from branches to speciation events impacts inference of branching times in phylogenetic reconstruction. Furthermore, the resulting nucleotide alignments are better described by a relaxed than by a strict molecular clock. Thus, elevated mutation rates during speciation potentially explain part of the variation in substitution rates that is observed across the tree of life. [Molecular clock; phylogenetic reconstruction; speciation; substitution rate variation.].
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