Evidence map›Paper›PMID 34672258›Full record

ArticleeLife2021

Ciliary Hedgehog signaling regulates cell survival to build the facial midline.

Shaun R Abrams, Jeremy F Reiter

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Early Deletion ofFrontiers in cell and developmental biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Shaun R AbramsDepartment of Biochemistry and Biophysics, Cardiovascular Research Institute, San Francisco, United States.ORCID 0000-0002-1479-9322
Jeremy F ReiterDepartment of Biochemistry and Biophysics, Cardiovascular Research Institute, San Francisco, United States.ORCID 0000-0002-6512-320X
Cardiovascular Institute Hospital · JP

Funding

Hedgehog signaling at the cell's antenna: Smoothened and the primary ciliumR01AR054396 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jeremy F Reiter · 2007 to 2026
$9.0M
Transition zone control of ciliary signalingR01DE029454 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI REITER, JEREMY F · 2019 to 2022
$2.3M
Role of the Primary Cilia Transition Zone Complex in Craniofacial CiliopathiesF30DE024684 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ABRAMS, SHAUN · 2014 to 2019
$277k
NIAMS NIH HHS R01 AR054396NIDCR NIH HHS F30 DE024684NIDCR NIH HHS R01 DE029454
6 · The paper itself

Abstract

Craniofacial defects are among the most common phenotypes caused by ciliopathies, yet the developmental and molecular etiology of these defects is poorly understood. We investigated multiple mouse models of human ciliopathies (including

Indexed as

Cell SurvivalAnimalsApoptosisCiliopathiesCraniofacial AbnormalitiesDisease Models, AnimalHedgehog ProteinsMiceMice, KnockoutSignal TransductionHedgehog Proteinsapoptosiscell biologyciliopathycraniofacial developmentdependence receptordevelopmental biologyHedgehog signalingmouseprimary cilia

Identifiers

PMID34672258
PMCPMC8592574
OpenAlexW3206445999

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.