Evidence map›Paper›PMID 34672048›Full record

ArticleThe European journal of neuroscience2021

Experiential modulation of social dominance in a SYNGAP1 rat model of Autism Spectrum Disorders.

Emma Harris, Honor Myers, Kapil Saxena, Rufus Mitchell-Heggs, Peter Kind, Shona Chattarji, Richard G M Morris

Open access · greenAbstract read
In one paragraph

Article in The European journal of neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Ca2+ imaging of self and other in medial prefrontal cortex during social dominance interactions in a tube test.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  10. Article
  11. Roadmap to advance therapeutics forTherapeutic advances in rare disease
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Emma HarrisEdinburgh Neuroscience, Centre for Discovery Brain Sciences, 1 George Square, The University of Edinburgh, Edinburgh, UK.
Honor MyersEdinburgh Neuroscience, Centre for Discovery Brain Sciences, 1 George Square, The University of Edinburgh, Edinburgh, UK.
Kapil SaxenaEdinburgh Neuroscience, Centre for Discovery Brain Sciences, 1 George Square, The University of Edinburgh, Edinburgh, UK.
Rufus Mitchell-HeggsEdinburgh Neuroscience, Centre for Discovery Brain Sciences, 1 George Square, The University of Edinburgh, Edinburgh, UK.
Peter KindEdinburgh Neuroscience, Centre for Discovery Brain Sciences, 1 George Square, The University of Edinburgh, Edinburgh, UK.
Shona ChattarjiSimons Initiative for the Developing Brain, The University of Edinburgh, Edinburgh, UK.
Richard G M MorrisEdinburgh Neuroscience, Centre for Discovery Brain Sciences, 1 George Square, The University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-8661-1520
MRC Centre for Regenerative Medicine · GBNational Centre for Biological Sciences · IN

Funding

Wellcome Trust 207481Wellcome Trust 207481/Z/17/Z
6 · The paper itself

Abstract

Advances in the understanding of developmental brain disorders such as autism spectrum disorders (ASDs) are being achieved through human neurogenetics such as, for example, identifying de novo mutations in SYNGAP1 as one relatively common cause of ASD. A recently developed rat line lacking the calcium/lipid binding (C2) and GTPase activation protein (GAP) domain may further help uncover the neurobiological basis of deficits in children with ASD. This study focused on social dominance in the tube test using Syngap

Indexed as

Autism Spectrum DisorderAnimalsGenotypeMalePhenotypeRatsSocial BehaviorSocial Dominanceautism spectrum disorderscognitive compensationsocial dominancesocial neurosciencetube test

Identifiers

PMID34672048
PMCPMC7614819
OpenAlexW3196270558

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.