Evidence map›Paper›PMID 34672005›Full record

Observational studyEchocardiography (Mount Kisco, N.Y.)2021

Subclinical myocardial dysfunction in patients recovered from COVID-19.

Leonardo Italia, Giacomo Ingallina, Antonio Napolano, Antonio Boccellino, Martina Belli, Francesco Cannata, Marco Rolando, Francesco Ancona, Francesco Melillo, Stefano Stella and 12 more

Abstract readObservational Study
In one paragraph

Observational study in Echocardiography (Mount Kisco, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Prevalence, risk factors and treatments for post-COVID-19 breathlessness: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2022
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
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  8. Review
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  10. Myocardial performance index: Is it time to revisit this old parameter in COVID-19 patients?Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology · 2022
    Article
  11. Article
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  14. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Leonardo ItaliaCardiovascular Imaging Unit, San Raffaele Scientific Institute, Milan, Italy.
Giacomo IngallinaCardiovascular Imaging Unit, San Raffaele Scientific Institute, Milan, Italy.
Antonio NapolanoCardiovascular Imaging Unit, San Raffaele Scientific Institute, Milan, Italy.
Antonio BoccellinoCardiovascular Imaging Unit, San Raffaele Scientific Institute, Milan, Italy.
Martina BelliCardiovascular Imaging Unit, San Raffaele Scientific Institute, Milan, Italy.
Francesco CannataCardiovascular Imaging Unit, San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0002-5842-5293
Marco RolandoCardiovascular Imaging Unit, San Raffaele Scientific Institute, Milan, Italy.
Francesco AnconaCardiovascular Imaging Unit, San Raffaele Scientific Institute, Milan, Italy.
Francesco MelilloCardiovascular Imaging Unit, San Raffaele Scientific Institute, Milan, Italy.
Stefano StellaCardiovascular Imaging Unit, San Raffaele Scientific Institute, Milan, Italy.
Marco RipaDepartment of Infectious Disease, San Raffaele Scientific Institute, Milan, Italy.
Paolo ScarpelliniDepartment of Infectious Disease, San Raffaele Scientific Institute, Milan, Italy.
Moreno TresoldiDepartment of General Medicine and Advanced Care, San Raffaele Scientific Institute, Milan, Italy.
Alessandro OrtaldaDepartment of Anesthesia and Intensive Care, San Raffaele Scientific Institute, Milan, Italy.
Beatrice RighettiDepartment of Anesthesia and Intensive Care, San Raffaele Scientific Institute, Milan, Italy.
Francesco De CobelliVita-Salute San Raffaele University, Milan, Italy.
Antonio EspositoVita-Salute San Raffaele University, Milan, Italy.
Fabio CiceriVita-Salute San Raffaele University, Milan, Italy.
Antonella CastagnaDepartment of Infectious Disease, San Raffaele Scientific Institute, Milan, Italy.
Patrizia Querini RovereVita-Salute San Raffaele University, Milan, Italy.
Gabriele FragassoHeart Failure Clinic, Clinical Cardiology, San Raffaele Scientific Institute, Milan, Italy.
Eustachio AgricolaCardiovascular Imaging Unit, San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0002-4834-2187

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMyocardial injury (MI) can be detected during the acute phase of Coronavirus disease 19 (COVID-19) and is associated with a dismal prognosis. Recent imaging studies described the persistence of cardiac abnormalities after the recovery. The aim of the study was to investigate the spectrum of cardiac abnormalities at mid-term follow-up in patients recovered from COVID-19 using clinical assessment, laboratory tests, and imaging evaluation with comprehensive echocardiography.

methodsThis is an observational, cross-sectional study assessing an unselected cohort of consecutive patients recovered from COVID-19. MI was defined by elevated plasma levels of high sensitive troponin T (hsTnT). At the follow-up, a complete examination including echocardiography was performed.

resultsThe 123 patients included were divided into two groups according to the presence of MI during hospitalization: group A (without MI) and group B (with MI). After a median of 85 days, group B patients were more frequently symptomatic for dyspnea and had significantly higher values of hsTnT and N-Terminal prohormone of Brain Natriuretic Peptide (NT-proBNP), compared to Group A. No differences between the two groups in left nor right ventricle dimension and ejection fraction were found. However, in group B a significant reduction of mean left ventricle global longitudinal strain was observed (-15.7±.7 vs -18.1± .3 in group A, p < 0.001), together with higher frequency of impaired diastolic function and higher values of pulmonary pressure.

conclusionsIn patients recovered from COVID-19, echocardiography with speckle-tracking analysis may be an useful imaging tool to identify subclinical myocardial dysfunction and potentially guide management strategies.

Indexed as

COVID-19Cross-Sectional StudiesEchocardiographyHeartHumansMyocardiumNatriuretic Peptide, BrainPeptide FragmentsStroke VolumeVentricular Function, LeftNatriuretic Peptide, BrainPeptide FragmentsCOVID-19echocardiographyheart failuremyocarditisstrain

Identifiers

PMID34672005
PMCPMC8652678

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.