Evidence map›Paper›PMID 34671820›Full record

GuidelineEuropean journal of nuclear medicine and molecular imaging2022

The EANM guideline for radiosynoviorthesis.

W U Kampen, B Boddenberg-Pätzold, M Fischer, M Gabriel, R Klett, M Konijnenberg, E Kresnik, H Lellouche, F Paycha, L Terslev and 8 more

Open access · hybridAbstract readPractice Guideline
In one paragraph

Guideline in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
  2. Updates in ultrasound-guided musculoskeletal interventions.The British journal of radiology · 2026
    Review
  3. Zeitschrift fur Rheumatologie · 2026
    Article
  4. Zeitschrift fur Rheumatologie · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. ABiomaterials · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Treatment of Chronic Haemophilic Synovitis with PRP: Clinical andInternational journal of molecular sciences · 2024
    Article
  15. Article
  16. Radiosynoviorthesis in Activated Osteoarthritis.Deutsches Arzteblatt international · 2024
    Article
  17. Article
  18. Review
  19. Cost Analysis of Radioactive Versus Arthroscopic Synovectomy in Haemophilia: A Brazilian Modelling Approach.Haemophilia : the official journal of the World Federation of Hemophilia
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 12 institutions in 10 countries.

W U KampenNuklearmedizin Spitalerhof, Radiologische Allianz, Spitalerstraße 8, 20095, Hamburg, Germany.
B Boddenberg-PätzoldPraxis NURAMED West, Max-Planck-Straße 27a, 50858, Köln, Germany.
M FischerPraxis Für Radiologie Und Nuklearmedizin, Friedrich-Ebert-Straße 50, 34117, Kassel, Germany.
M GabrielInstitute of Nuclear Medicine and Endocrinology, Kepler University Hospital Linz GmbH, Medical Faculty, Johannes Kepler University Linz, Altenberger Strasse 69, 4040 Linz and Krankenhausstrasse 9, 4020, Linz, Austria.
R KlettÜBAG Für Nuklearmedizin, Hanau-Frankfurt-Offenbach-Gießen, Standort Gießen, Paul-Zipp-Str. 171-173, 35398, Gießen, Germany.
M KonijnenbergErasmus MC, Nucleaire geneeskunde, Dr. Molewaterplein 40, 3015 GD, Rotterdam, Netherlands.
E KresnikPrivatklinik Villach, Institut Für Nuklearmedizin, Dr.-Walter-Hochsteinerstrasse 4, 9504, Warmbad Villach, Austria.
H LelloucheUnité Rhumatologique de Affections de La Main, Centre Viggo Petersen, Hôpital Lariboisiere, 2 rue Ambroise Paré, 75010, Paris, France.
F PaychaService de Médecine Nucléaire, Hôpital Lariboisière, Assistance Publique- Hôpitaux de Paris, 2 rue Ambroise Paré, 75010, Paris, France.
L TerslevCenter for Rheumatology and Spine Diseases, Copenhagen University Hospital, Rigshospitalet, Valdemar Hansens Vej 17, 2600, Glostrup, Denmark.
C TurkmenDepartment of Nuclear Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, 34390, Turkey.
F van der ZantNucleaire Geneeskunde, Noordwest Ziekenhuisgroep, Postbus 501, 1800 AM, Alkmaar, Netherlands.
L AntunovicDiagnostic Imaging Department, IRCCS Humanitas Research Hospital, Via Manzoni 56, Milan, 20089, Rozzano, Italy.
E PanagiotidisDepartment of Nuclear Medicine, Oncology Center 'Theageneio', Al Symeonidis 2 str, P.C 54007, Thessaloniki, Greece.
G GnanasegaranDepartment of Nuclear Medicine, Royal Free London NHS Foundation Trust, London, UK.
T KuwertClinic of Nuclear Medicine, Friedrich-Alexander-University, Erlangen-Nürnberg, Erlangen, Germany. torsten.kuwert@uk-erlangen.de.
T Van den WyngaertAntwerp University Hospital, Drie Eikenstraat 655, 2650, Edegem, Belgium.
EANM Bone & Joint Committee, the Dosimetry Committee, the Oncology & Theranostics Committee
Hôpital Lariboisière · FRErasmus MC · NLFriedrich-Alexander-Universität Erlangen-Nürnberg · DEIRCCS Humanitas Research Hospital · ITIstanbul University · TRKepler Universitätsklinikum · ATNoordwest Ziekenhuisgroep · NLOrthopädische Praxis · DERigshospitalet · DKRoyal Free London NHS Foundation Trust · GBTheageneio General Hospital · GRUniversity of Antwerp · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRadiosynoviorthesis (RSO) using the intraarticular application of beta-particle emitting radiocolloids has for decades been used for the local treatment of inflammatory joint diseases. The injected radiopharmaceuticals are phagocytized by the superficial macrophages of the synovial membrane, resulting in sclerosis and fibrosis of the formerly inflamed tissue, finally leading to reduced joint effusion and alleviation of joint pain.

methodsThe European Association of Nuclear Medicine (EANM) has written and approved these guidelines in tight collaboration with an international team of clinical experts, including rheumatologists. Besides clinical and procedural aspects, different national legislative issues, dosimetric considerations, possible complications, and side effects are addressed.

conclusionThese guidelines will assist nuclear medicine physicians in performing radiosynoviorthesis. Since there are differences regarding the radiopharmaceuticals approved for RSO and the official indications between several European countries, this guideline can only give a framework that must be adopted individually.

Indexed as

Nuclear MedicineEuropeHumansRadionuclide ImagingRadiopharmaceuticalsRadiopharmaceuticalsArthritisRadiosynoviorthesisSynovitis

Identifiers

PMID34671820
PMCPMC8803784
OpenAlexW3205127776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.