Evidence map›Paper›PMID 34671779›Full record

ArticlemedRxiv : the preprint server for health sciences2021

Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapy.

Zabrina L Brumme, Francis Mwimanzi, Hope R Lapointe, Peter Cheung, Yurou Sang, Maggie C Duncan, Fatima Yaseen, Olga Agafitei, Siobhan Ennis, Kurtis Ng and 33 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 23 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

43 authors at 7 institutions in 1 country.

Zabrina L BrummeFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
Francis MwimanziFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
Hope R LapointeBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Peter CheungFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
Yurou SangFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
Maggie C DuncanFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
Fatima YaseenDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, Canada.
Olga AgafiteiFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
Siobhan EnnisFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
Kurtis NgFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
Simran BasraFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
Li Yi LimFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
Rebecca KalikaweFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
Sarah SpeckmaierBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Nadia Moran-GarciaBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Landon YoungDivision of Medical Microbiology and Virology, St. Paul's Hospital, Vancouver, Canada.
Hesham AliJohn Ruedy Clinic, St, Paul's Hospital, Vancouver, Canada.
Bruce GanaseAIDS Research Program, St. Paul's Hospital, Vancouver, Canada.
Gisele UmviligihozoFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
F Harrison OmondiFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
Kieran AtkinsonBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Hanwei SudderuddinBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Junine ToyBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Paul SeredaBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Laura BurnsDepartment of Pathology and Laboratory Medicine, Providence Health Care, Vancouver, Canada.
Cecilia T CostiniukDivision of Infectious Diseases and Chronic Viral Illness Service, McGill University Health Centre and Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Curtis CooperDepartment of Medicine, University of Ottawa, Ottawa, Canada.
Aslam H AnisSchool of Population and Public Health, University of British Columbia, Vancouver, Canada.
Victor LeungDivision of Medical Microbiology and Virology, St. Paul's Hospital, Vancouver, Canada.
Daniel HolmesDepartment of Pathology and Laboratory Medicine, Providence Health Care, Vancouver, Canada.
Mari L DeMarcoDepartment of Pathology and Laboratory Medicine, Providence Health Care, Vancouver, Canada.
Janet SimonsDepartment of Pathology and Laboratory Medicine, Providence Health Care, Vancouver, Canada.
Malcolm HedgcockSpectrum Health, Vancouver, Canada.
Marc G RomneyDivision of Medical Microbiology and Virology, St. Paul's Hospital, Vancouver, Canada.
Rolando BarriosBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Silvia GuillemiBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Chanson J BrummeBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Ralph PantophletFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
Julio S G MontanerBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Masahiro NiikuraFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
Marianne HarrisBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Mark HullBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Mark A BrockmanFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
Simon Fraser University · CAUniversity of British Columbia · CAAIDS Vancouver · CAProvidence Health Care · CASt. Paul's Hospital · CAMcGill University Health Centre · CAUniversity of Ottawa · CA

Funding

Wellcome Trust
6 · The paper itself

Abstract

Humoral responses to COVID-19 vaccines in people living with HIV (PLWH) remain incompletely understood. We measured circulating antibodies against the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein, ACE2 displacement and live viral neutralization activities one month following the first and second COVID-19 vaccine doses in 100 adult PLWH and 152 controls. All PLWH were receiving suppressive antiretroviral therapy, with median CD4+ T-cell counts of 710 (IQR 525-935) cells/mm

Identifiers

PMID34671779
PMCPMC8528088
OpenAlexW3202230305

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.