Evidence map›Paper›PMID 34671680›Full record

ArticleBioMed research international2021

Effects of High-Flux Dialysis Combined with Hemoperfusion on Serum GRP78 and miR-495-3p in Renal Failure Patients.

Wei Fan, Xudong Li, Xiangjun Xu, Hong Chu

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Wei FanDepartment of Nephrology, Affiliated Yixing People's Hospital of Jiangsu University, Wuxi, 214200 Jiangsu Povince, China.
Xudong LiDepartment of Nephrology, Affiliated Yixing People's Hospital of Jiangsu University, Wuxi, 214200 Jiangsu Povince, China.
Xiangjun XuDepartment of Nephrology, Affiliated Yixing People's Hospital of Jiangsu University, Wuxi, 214200 Jiangsu Povince, China.
Hong ChuDepartment of Nephrology, Affiliated Yixing People's Hospital of Jiangsu University, Wuxi, 214200 Jiangsu Povince, China.ORCID https://orcid.org/0000-0001-7906-9825
Jiangsu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study was designed to probe into the changes and clinical significance of GRP78 and miR-495-3p in renal failure (RF) patients during high-flux dialysis (HFD) combined with hemoperfusion (HP).

methodsSixty-five RF patients and 74 health check-ups who were admitted in our hospital from March 2015 to February 2017 were prospectively selected, and the related characteristics were retrospectively collected for analysis. GRP78 and miR-495-3p were detected in RF patients at admission (before treatment), 12 weeks after treatment (during treatment), 24 weeks after treatment (after treatment), and the control group at admission, and the relationship between the two and the occurrence, efficacy, and recurrence of RF was analyzed.

resultsBefore treatment, the GRP78 mRNA level in RF patients was higher than that in health check-ups, while the miR-495-3p level was lower (

conclusionGRP78 decreased during the treatment of high-flux hemodialysis (HF-HD) combined with systemic HP in RF patients, while miR-495-3p increased. Both of them have a good reference value for RF occurrence, treatment results, and recurrence.

Indexed as

BiomarkersEndoplasmic Reticulum Chaperone BiPFemaleHemoperfusionHumansMaleMicroRNAsMiddle AgedPrognosisProspective StudiesRenal DialysisRenal InsufficiencyRetrospective StudiesROC CurveTreatment OutcomeBiomarkersEndoplasmic Reticulum Chaperone BiPHSPA5 protein, humanMicroRNAsMIRN495 microRNA, human

Identifiers

PMID34671680
PMCPMC8523225
OpenAlexW3206791392

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.