Evidence map›Paper›PMID 34671466›Full record

ArticleClinical kidney journal2021

Proteinuria and venous thromboembolism in pregnancy: a population-based cohort study.

Ayub Akbari, Elizabeth Kunkel, Sarah E Bota, Ziv Harel, Gregoire Le Gal, Conor Cox, Gregory L Hundemer, Mark Canney, Edward Clark, David Massicotte-Azarniouch and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical kidney journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ayub AkbariDepartment of Medicine, Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
Elizabeth KunkelICES, Toronto, ON, Canada.
Sarah E BotaICES, Toronto, ON, Canada.
Ziv HarelDepartment of Medicine, University of Toronto, Toronto, ON, Canada.
Gregoire Le GalDepartment of Medicine, Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
Conor CoxDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Gregory L HundemerDepartment of Medicine, Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
Mark CanneyDepartment of Medicine, Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
Edward ClarkDepartment of Medicine, Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.ORCID https://orcid.org/0000-0002-6767-1197
David Massicotte-AzarniouchDepartment of Medicine, Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.ORCID https://orcid.org/0000-0002-6954-2030
Anan Bader EddeenICES, Toronto, ON, Canada.
Greg KnollDepartment of Medicine, Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
Manish M SoodDepartment of Medicine, Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPregnancy-associated venous thromboembolism (VTE) is associated with high morbidity and mortality. Identification of risk factors of VTE may lead to improved maternal and foetal outcomes. Proteinuria confers a pro-thrombotic state, however, its association with VTE in pregnancy remains unknown. We set out to assess the association of proteinuria and VTE during pregnancy.

methodsWe conducted a population-based, retrospective cohort study of all pregnant women (≥16 years of age) with a proteinuria measure within 20 weeks of conception (

resultsA positive proteinuria measurement occurred in 8508 (2.78%) women and was more common with a history of kidney disease, gestational or non-gestational diabetes mellitus and hypertension. VTE events occurred in 625 (0.20%) individuals, with a higher risk among women with positive proteinuria [32 events (0.38%)] compared with women without proteinuria [593 events (0.20%); inverse probability-weighted risk ratio 1.79 (95% confidence interval 1.25-2.57)]. The association was consistent using a more specific VTE definition, in the post-partum period, in high-risk subgroups (hypertension or diabetes) and when the sample was restricted to women with preserved kidney function.

conclusionsThe presence of proteinuria in the first 20 weeks of pregnancy is associated with a significantly higher risk of VTE.

Indexed as

kidney functionpre-eclampsiapregnancyproteinuriavenous thromboembolism

Identifiers

PMID34671466
PMCPMC8521786

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.