ArticleComputational and mathematical methods in medicine2021
Predicting Cross-Species Infection of Swine Influenza Virus with Representation Learning of Amino Acid Features.
Article in Computational and mathematical methods in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Predicting host species susceptibility to influenza viruses and coronaviruses using genome data and machine learning: a scoping review.Frontiers in veterinary science · 2024Article
- Using amino acid features to identify the pathogenicity of influenza B virus.Infectious diseases of poverty · 2022Article
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Authors and funding
5 authors.
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Abstract
Swine influenza viruses (SIVs) can unforeseeably cross the species barriers and directly infect humans, which pose huge challenges for public health and trigger pandemic risk at irregular intervals. Computational tools are needed to predict infection phenotype and early pandemic risk of SIVs. For this purpose, we propose a feature representation algorithm to predict cross-species infection of SIVs. We built a high-quality dataset of 1902 viruses. A feature representation learning scheme was applied to learn feature representations from 64 well-trained random forest models with multiple feature descriptors of mutant amino acid in the viral proteins, including compositional information, position-specific information, and physicochemical properties. Class and probabilistic information were integrated into the feature representations, and redundant features were removed by feature space optimization. High performance was achieved using 20 informative features and 22 probabilistic information. The proposed method will facilitate SIV characterization of transmission phenotype.
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