ArticleFrontiers in endocrinology2021
Association Between Age at Diagnosis of Type 2 Diabetes and Cardiovascular Diseases: A Nationwide, Population-Based, Cohort Study.
Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Association between younger-onset type 2 diabetes and long-term risk of CVD events: a 34-year follow-up of the Da Qing Diabetes Prevention Study.Endocrine connections · 2026Article
- Butyrate-Mediated Upregulation of Insulin Pathway Gene Expression Suggests Potential Antidiabetic Effects.Drug development research · 2025Article
- Impact of albuminuria on early-onset type 2 diabetes mellitus: a nationwide population-based study.Kidney research and clinical practice · 2025Article
- Life's essential 8 and risk of progression to diabetes among young adults with prediabetes.Scientific reports · 2025Article
- Young patients with type 2 diabetes have high relative risks for complications in a country with middle-high sociodemographic index, similarly to those countries with high index.Frontiers in endocrinology · 2025Review
- Article
- Sexual dysfunction, depression, and marital adjustment in diabetic male patients.Indian journal of psychiatry · 2024Article
- Association between age at diagnosis and all-cause mortality in type 2 diabetes: the Renal Insufficiency and Cardiovascular Events (RIACE) Italian Multicenter Study.Acta diabetologica · 2024Observational
- Article
- Incident Cancer Risk in Patients with Incident Type 2 Diabetes Mellitus in Hungary (Part 1).Cancers · 2024Article
- Hypertension combined with atherosclerosis increases the risk of heart failure in patients with diabetes.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Cardiovascular disease risk in early-onset vs late-onset type 2 diabetes in China: A population-based cross-sectional study.Journal of diabetes · 2024Article
- Age at diagnosis of diabetes, obesity, and the risk of dementia among adult patients with type 2 diabetes.PloS one · 2024Article
- Association Between Serum Magnesium Levels and Glycemic Control in Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Letter to the editor: alarming prevalence of comorbid conditions in adults with type 2 diabetes in Iran.Journal of diabetes and metabolic disorders · 2023Article
- Youth-onset type 2 diabetes mellitus: an urgent challenge.Nature reviews. Nephrology · 2023Review
- Association between diabetes at different diagnostic ages and risk of cancer incidence and mortality: a cohort study.Frontiers in endocrinology · 2023Article
- Cellular enlargement - A new hallmark of aging?Frontiers in cell and developmental biology · 2022Review
- Risk of periodontitis & dental caries among 35 to 44 year old diabetic individuals: A case control study.Journal of Indian Society of PeriodontologyArticle
- Exploring the thoughts, emotions, and behaviours related to the self-management practices of adults with type 2 diabetes.Health psychology openArticle
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Authors and funding
47 authors at 20 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Nationwide studies focusing on the impact of early-onset type 2 diabetes and obesity on the development of cardiovascular diseases (CVD) are limited in China. We aimed to investigate the association between age at diagnosis of type 2 diabetes and the risk of CVD, and to further examine the modifying effect of obesity on this association among Chinese adults. Methods: This study included 23,961 participants with previously diagnosed diabetes from a large nationwide population-based cohort study across mainland China. With an interviewer-assisted questionnaire, we collected detailed information on CVDs. Logistic regression analysis was used to evaluate the risk of CVDs associated with age at diagnosis of diabetes. Results: Compared with patients with late-onset diabetes (≥60 years), those with earlier-onset diabetes had increased risks for CVD, with adjusted ORs (95% CIs) of 1.72 (1.36-2.17), 1.52 (1.31-1.75) and 1.33 (1.19-1.48) for patients diagnosed aged <40, 40-49 and 50-59 years, respectively. Each 5-year earlier age at diagnosis of type 2 diabetes was significantly associated with 14% increased risk of CVD (OR, 1.14; 95%CI, 1.11-1.18). This association was more prominent for patients with obesity than those with normal body mass index (BMI). Significant interaction was detected between age at diagnosis and BMI categories on CVD risk ( Conclusion: Early-onset type 2 diabetes was significantly associated with higher risk of CVD, and this association was more prominent among patients with obesity.
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