Evidence map›Paper›PMID 34671252›Full record

ArticleFrontiers in pharmacology2021

Deletion of PRAK Mitigates the Mitochondria Function and Suppresses Insulin Signaling in C2C12 Myoblasts Exposed to High Glucose.

Ling Zhang, Jianguo Wang, Yu Tina Zhao, Patrycja Dubielecka, Gangjian Qin, Shougang Zhuang, Eugene Y Chin, Paul Y Liu, Ting C Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Irisin deficiency exacerbates cardiac dysfunction and enhances hemorrhage injury in hemorrhage/resuscitation.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Ling ZhangDepartment of Medicine, Rhode Island Hospital, Alpert Brown Medical School, Brown University, Providence, RI, United States.
Jianguo WangDepartment of Surgery, Roger Williams Medical Center, Boston University School of Medicine, Boston, MA, United States.
Yu Tina ZhaoUniversity of Rochester School of Medicine and Dentistry, Rochester, NY, United States.
Patrycja DubieleckaDepartment of Medicine, Rhode Island Hospital, Alpert Brown Medical School, Brown University, Providence, RI, United States.
Gangjian QinDepartment of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, United States.
Shougang ZhuangDepartment of Medicine, Rhode Island Hospital, Alpert Brown Medical School, Brown University, Providence, RI, United States.
Eugene Y ChinInstitute of Health Sciences, Chinese Academy of Sciences-Jiaotong University School of Medicine, Shanghai, China.
Paul Y LiuDepartment of Surgery and Department of Plastic Surgery, Rhode Island Hospital, Brown University, Providence, RI, United States.
Ting C ZhaoDepartment of Surgery, Roger Williams Medical Center, Boston University School of Medicine, Boston, MA, United States.
Brown University · USBoston University · USChinese Academy of Sciences · CNRhode Island Hospital · USUniversity of Alabama at Birmingham · USUniversity of Rochester · US

Funding

Histone Deacetylase Inhibition: A Novel Approach to CardioprotectionR01HL089405 · NHLBI · ROGER WILLIAMS MEDICAL CENTER · PI ZHAO, TING C · 2009 to 2020
$3.4M
A novel protective mechanism in hemorrhagic shockR01GM141339 · NIGMS · RHODE ISLAND HOSPITAL · PI ZHAO, TING C · 2021 to 2025
$1.7M
p38 acetylation: Novel signaling mechanisms and myocardial protectionR01HL115265 · NHLBI · ROGER WILLIAMS MEDICAL CENTER · PI ZHAO, TING C · 2013 to 2016
$1.6M
NHLBI NIH HHS R01 HL089405NHLBI NIH HHS R01 HL115265NIGMS NIH HHS R01 GM141339
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

C2C12 myoblastshigh glucoseinsulin signalingmetabolic stressmitochondria

Identifiers

PMID34671252
PMCPMC8521062
OpenAlexW3204989160

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.