ArticleFrontiers in neuroscience2021
Bridging the Gap Between Morphometric Similarity Mapping and Gene Transcription in Alzheimer's Disease.
Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 13 citations in OpenAlex.
- Application of the Allen Human Brain Atlas in Alzheimer's disease and Parkinson's disease.Translational neurodegeneration · 2026Review
- Gray Matter Morphological Networks are Associated with Neurobiological Features, Cognitive Status and Clinical Recovery in Traumatic Brain Injury.medRxiv : the preprint server for health sciences · 2026Article
- Cell-specific mechanisms drive connectivity across the time course of Huntington's disease.Nature communications · 2025Article
- Cortical Morphometric Similarity Remodeling in Traumatic Brain Injury Links Cognitive Impairments with Transcriptional Changes and Type-Specific Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Cortical morphometric similarity gradient in schizophrenia and its association with transcriptional profiles and clinical phenotype.Psychological medicine · 2025Article
- Structural MRI of brain similarity networks.Nature reviews. Neuroscience · 2025Review
- Morphometric Similarity Patterning of Amyloid-International journal of molecular sciences · 2024Article
- Altered morphometric similarity networks in insomnia disorder.Brain structure & function · 2024Article
- Morphometric similarity differences in drug-naive Parkinson's disease correlate with transcriptomic signatures.CNS neuroscience & therapeutics · 2024Article
- Robust estimation of cortical similarity networks from brain MRI.Nature neuroscience · 2023Article
- Association between gene expression and altered resting-state functional networks in type 2 diabetes.Frontiers in aging neuroscience · 2023Article
- Alzheimer's genetic risk effects on cerebral blood flow across the lifespan are proximal to gene expression.Neurobiology of aging · 2022Article
- Brain morphometric similarity and flexibility.Cerebral cortex communications · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Disruptions in brain connectivity have been widely reported in Alzheimer's disease (AD). Morphometric similarity (MS) mapping provides a new way of estimating structural connectivity by interregional correlation of T1WI- and DTI-derived parameters within individual brains. Here, we aimed to identify AD-related MS changing patterns and genes related to the changes and further explored the molecular and cellular mechanism underlying MS changes in AD. Both 3D-T1WI and DTI data of 106 AD patients and 106 well-matched healthy elderly individuals from the ADNI database were included in our study. Cortical regions with significantly decreased MS were found in the temporal and parietal cortex, increased MS was found in the frontal cortex and variant changes were found in the occipital cortex in AD patients. Mean MS in regions with significantly changed MS was positively or negatively associated with memory function. Negative MS-related genes were significantly downregulated in AD, specifically enriched in neurons, and participated in biological processes, with the most significant term being synaptic transmission. This study revealed AD-related cortical MS changes associated with memory function. Linking gene expression to cortical MS changes may provide a possible molecular and cellular substrate for MS abnormality and cognitive decline in AD.
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