ReviewGreen chemistry : an international journal and green chemistry resource : GC2021
Continuous flow asymmetric synthesis of chiral active pharmaceutical ingredients and their advanced intermediates.
Review in Green chemistry : an international journal and green chemistry resource : GC, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods.Chirality · 2026Review
- Integrating biocatalysis with continuous flow: current status, challenges, and future perspectives.Journal of advanced research · 2026Review
- Enantioselective Organophotocatalytic α-Functionalization of Aldehydes withOrganic letters · 2025Article
- Asymmetric phase-transfer catalysis.Nature reviews. Chemistry · 2024Review
- Co-immobilization of amine dehydrogenase and glucose dehydrogenase for the biosynthesis of (S)-2-aminobutan-1-ol in continuous flow.Bioresources and bioprocessing · 2024Article
- Continuous Enantioselective α-Alkylation of Ketones via Direct Photoexcitation.The Journal of organic chemistry · 2024Article
- Stereoselective Asymmetric Syntheses of Molecules with a 4,5-Dihydro-1Molecules (Basel, Switzerland) · 2024Article
- Recent Advances in the Domino Annulation Reaction of Quinone Imines.Molecules (Basel, Switzerland) · 2024Review
- A New 2-Aminospiropyrazolylammonium Cation with Possible Uses in the Topical Areas of Ionic Liquids.Molecules (Basel, Switzerland) · 2024Review
- Optical Phenomena in Molecule-Based Magnetic Materials.Chemical reviews · 2024Review
- Investigating the efficacy of green solvents and solvent-free conditions in hydrogen-bonding mediated organocatalyzed model reactions.RSC advances · 2024Article
- A Telescoped Continuous Flow Enantioselective Process for Accessing Intermediates of 1-Aryl-1,3-diols as Chiral Building Blocks.The Journal of organic chemistry · 2023Article
- Synthesis of the Brivaracetam Employing Asymmetric Photocatalysis and Continuous Flow Conditions.ACS omega · 2023Article
- Harnessing a Continuous-Flow Persulfuric Acid Generator for Direct Oxidative Aldehyde Esterifications.ChemSusChem · 2023Article
- Continuous Flow Biocatalytic Reductive Amination by Co-Entrapping Dehydrogenases with Agarose Gel in a 3D-Printed Mould Reactor.Chembiochem : a European journal of chemical biology · 2022Article
- Asymmetric Michael Addition in Synthesis of β-Substituted GABA Derivatives.Molecules (Basel, Switzerland) · 2022Review
- Photochemical CPhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2022Article
- Understanding flow chemistry for the production of active pharmaceutical ingredients.iScience · 2022Review
- Enantioselective Flow Synthesis of Rolipram Enabled by a Telescoped Asymmetric Conjugate Addition-Oxidative Aldehyde Esterification Sequence UsingOrganic letters · 2022Article
- Advances on Greener Asymmetric Synthesis of Antiviral Drugs via Organocatalysis.Pharmaceuticals (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Catalytic enantioselective transformations provide well-established and direct access to stereogenic synthons that are broadly distributed among active pharmaceutical ingredients (APIs). These reactions have been demonstrated to benefit considerably from the merits of continuous processing and microreactor technology. Over the past few years, continuous flow enantioselective catalysis has grown into a mature field and has found diverse applications in asymmetric synthesis of pharmaceutically active substances. The present review therefore surveys flow chemistry-based approaches for the synthesis of chiral APIs and their advanced stereogenic intermediates, covering the utilization of biocatalysis, organometallic catalysis and metal-free organocatalysis to introduce asymmetry in continuously operated systems. Single-step processes, interrupted multistep flow syntheses, combined batch/flow processes and uninterrupted one-flow syntheses are discussed herein.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.