Evidence map›Paper›PMID 34671212›Full record

ArticleInternational journal of biological sciences2021

Long non-coding RNA MEG3 promotes cisplatin-induced nephrotoxicity through regulating AKT/TSC/mTOR-mediated autophagy.

Xu Jing, Jinming Han, Junhao Zhang, Yi Chen, Juan Yuan, Jue Wang, Shiyong Neo, Shuijie Li, Xueyuan Yu, Jing Wu

Open access · goldAbstract read
In one paragraph

Article in International journal of biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Light-Inducible Bispecific DNAzymes Reveal Mitochondrial FeAngewandte Chemie (International ed. in English) · 2026
    Article
  3. Review
  4. Elucidating the mechanism of traditional Chinese medicine formula (Journal of traditional and complementary medicine · 2026
    Article
  5. Review
  6. LncRNA AK154753 mediates the development of acute kidney ischemia reperfusion injury via the miRZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Xu JingDepartment of Clinical Laboratory, The Second Hospital of Shandong University, Jinan, 250000, China.
Jinming HanDepartment of Clinical Neuroscience, Karolinska Institutet, S-171 76, Sweden.
Junhao ZhangDepartment of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Yi ChenDepartment of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Juan YuanDepartment of Cell and Molecular Biology, Karolinska Institutet, S-171 76, Sweden.
Jue WangKey Laboratory, The Second Hospital of Shandong University, Jinan, 250000, China.
Shiyong NeoDepartment of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Shuijie LiDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, S-171 76, Sweden.
Xueyuan YuDepartment of Nephrology, Qilu hospital of Shandong University, Jinan, China.
Jing WuDepartment of Pharmacology, The Second Hospital of Shandong University, Jinan, 250000, China.
Karolinska Institutet · SENanfang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cis-Diamminedichloroplatinum (II) (DDP)-induced nephrotoxicity (DDPIN) may cause irreversible renal injury associated with high morbidity and mortality. Current standard therapies have not achieved satisfactory clinical outcomes due to unclear molecular and cellular mechanisms. Therefore, exploring potential therapies on DDPIN represents an urgent medical need. Present study characterized the role of lncRNA maternally expressed gene 3 (

Indexed as

Antineoplastic AgentsAutophagyCisplatinGene SilencingHumansProto-Oncogene Proteins c-aktRNA, Long NoncodingTOR Serine-Threonine KinasesTuberous SclerosisAntineoplastic AgentsCisplatinMEG3 non-coding RNA, humanMTOR protein, humanProto-Oncogene Proteins c-aktRNA, Long NoncodingTOR Serine-Threonine KinasesautophagyDDPINlncRNA MEG3miRNA-126

Identifiers

PMID34671212
PMCPMC8495387
OpenAlexW3207181981

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.