Evidence map›Paper›PMID 34671173›Full record

ArticleProceedings of the ... American Control Conference. American Control Conference2021

Modeling zebrafish geotaxis as a feedback control process.

Daniel A Burbano-L, Maurizio Porfiri

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the ... American Control Conference. American Control Conference, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Daniel A Burbano-LDept. of Mechanical and Aerospace Engineering, New York University, 6 MetroTech Center, NY, 11201, United States.
Maurizio PorfiriDept. of Mechanical and Aerospace Engineering, New York University, 6 MetroTech Center, NY, 11201, United States.
New York University · USProgress (Ireland) · IE

Funding

Robotics may help unravel the biological determinants of substance use disorders: studies in zebrafishR21DA042558 · NIDA · NEW YORK UNIVERSITY · PI PORFIRI, MAURIZIO · 2017 to 2018
$346k
NIDA NIH HHS R21 DA042558
6 · The paper itself

Abstract

Developing mathematical models of the feedback control process underlying animal behavior is of critical importance to understand their interactions with the environment and emotional responses. For instance, fish geotaxis (the tendency to swim at the bottom of the tank) is known to be a highly sensitive measure of anxiety, but how and why animals tend to display such a complex response is yet to be fully clarified. Leveraging the theory of stochastic differential equations, we develop a data-driven model of geotaxis in the form of a feedback control loop where fish use information about the hydrostatic pressure to dive towards the bottom of the tank. The proposed framework extends open-loop models by incorporating a simple, yet effective, control mechanism to explain geotaxis. We focus on the zebrafish animal model, which is a species of choice in the study of anxiety disorders. We calibrate the model using available experimental data on acute ethanol treatment of adult zebrafish, and demonstrate its effectiveness across a wide range of comparisons between theoretical predictions and empirical observations.

Identifiers

PMID34671173
PMCPMC8522050
OpenAlexW3183839804

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.