ArticleNature2021
KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 170 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
170citing papers in PubMed, 2 pooled it
14.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
170 citing papers in PubMed, 2 syntheses or guidelines pooled it, 248 citations in OpenAlex.
- Asystematic review and meta-analysis of clinical prognostic factors linked to extravesical recurrence after radical nephroureterectomy to treat upper tract urothelial carcinoma.Frontiers in oncology · 2024Pooled it
- Disrupting Mechanisms that Regulate Genomic Repeat Elements to Combat Cancer and Drug Resistance.Frontiers in cell and developmental biology · 2022Pooled it
- Nivolumab for mismatch-repair-deficient or hypermutated gynecologic cancers: a phase 2 trial with biomarker analyses.Nature medicine · 2024Trial
- Research progress on the molecular mechanisms of PD-1 and LAG-3 synergy in regulating T cell exhaustion and immunotherapy.Annals of medicine · 2026Review
- Viral mimicry escape as a necessary feature of malignant transformation.Nature reviews. Cancer · 2026Review
- Mutant TP53 hijacks RNA-splicing factor RBM28 to suppress double-stranded RNA triggered antitumor immunity.Nature communications · 2026Article
- JQKD82 Inhibits HIV Infection of Macrophages Through Blocking Viral Entry and Enhancing Antiviral ISG Responses.Journal of medical virology · 2026Article
- LINE-1 retrotransposons: Multifaceted functions and regulatory mechanisms in health and disease.Molecular therapy. Nucleic acids · 2026Review
- Identification of Novel Small-Molecule Inhibitors Targeting KDM5B and Evaluation of Their Antitumour Effects.Cancer medicine · 2026Article
- Argonaute 2 drives resistance to immune checkpoint inhibitors in immunorefractory non-small cell lung cancer.PLoS biology · 2026Article
- METTL3 Methylation Induces Decay of Endogenous Retroelement Transcripts to Promote Tumor Immune Evasion.Cancer research · 2026Article
- In vivo CRISPR screens identify CBX4 as an epigenetic regulator for cancer immunotherapy.The Journal of clinical investigation · 2026Article
- The Immune Landscape of Acral Melanoma: From Basic to Clinical.Cancer medicine · 2026Review
- Dual function of DOT1L suppresses tumor cell-intrinsic immunogenicity in hepatocellular carcinoma.Oncogene · 2026Article
- Article
- Co-occurrence of transcriptionally distinct persister cell states underpins neoadjuvant therapy resistance in triple‑negative breast cancer.Genome medicine · 2026Article
- Sustained interferon exposure creates a hyper-metastatic subset of melanoma cells.bioRxiv : the preprint server for biology · 2026Article
- The Many Faces of SetDB1.Epigenomes · 2026Review
- Apoptotic metabolites synthesize and inherit uniqueBioactive materials · 2026Article
- ERRα-KDM5C restrains STING enhancer activity to modulate type I interferon signaling in breast cancer progression.Cell death & disease · 2026Article
110 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
21 authors at 4 institutions in 2 countries.
Shang-Min ZhangDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA.
Wesley L CaiDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA.
Xiaoni LiuDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA.
Durga ThakralDepartment of Dermatology, Yale School of Medicine, New Haven, CT, USA.
Jiesi LuoSection of Cardiovascular Medicine, Department of Internal Medicine, Yale Cardiovascular Research Center, Yale School of Medicine, New Haven, CT, USA.
Lok Hei ChanDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA.
Meaghan K McGearyDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-8505-7158
Eric SongDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-5448-5865
Kim R M BlenmanDepartment of Dermatology, Yale School of Medicine, New Haven, CT, USA.
Goran MicevicDepartment of Dermatology, Yale School of Medicine, New Haven, CT, USA.
Shlomit JesselDepartment of Medicine, Yale School of Medicine, New Haven, CT, USA.
Yangyi ZhangDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA.
Mingzhu YinDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA.
Carmen J BoothDepartment of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-2153-738X
Lucia B JilaveanuDepartment of Medicine, Yale School of Medicine, New Haven, CT, USA.
William DamskyDepartment of Dermatology, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-0975-4071
Mario SznolDepartment of Dermatology, Yale School of Medicine, New Haven, CT, USA.
Harriet M KlugerDepartment of Medicine, Yale School of Medicine, New Haven, CT, USA.
Akiko IwasakiDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-7824-9856
Marcus W BosenbergDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA. marcus.bosenberg@yale.edu.ORCID http://orcid.org/0000-0003-0166-1612
Qin YanDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA. qin.yan@yale.edu.ORCID http://orcid.org/0000-0003-4077-453X
Yale University · USYale Cancer Center · USCentral South University · CNHoward Hughes Medical Institute · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MYale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI MEGAN C KING · 1985 to 2026
$85.0MYale SPORE in Skin CancerP50CA121974 · NCI · YALE UNIVERSITY · PI RUTH HALABAN · 2006 to 2026
$43.9MTumor Assessment CoreP01CA128814 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI SMITH, JEFFREY W · 2009 to 2020
$19.1MTraining in Investigative DermatologyT32AR007016 · NIAMS · YALE UNIVERSITY · PI KEITH A CHOATE, MICHAEL GIRARDI · 1986 to 2026
$7.8M(8) Mechanisms of autoimmune endocrine diseases in patients receiving checkpoint inhibitorsR01CA227473 · NCI · YALE UNIVERSITY · PI HEROLD, KEVAN C, KLUGER, HARRIET M. · 2018 to 2022
$3.2MRenalase inhibition for treatment of unresectable melanomaR01CA216846 · NCI · YALE UNIVERSITY · PI DESIR, GARY V., KLUGER, HARRIET M. · 2017 to 2021
$2.4MTARGETING HISTONE DEMETHYLASE KDM5B IN BREAST CANCERR01CA237586 · NCI · YALE UNIVERSITY · PI YAN, QIN · 2019 to 2023
$1.9MNCATS NIH HHS UL1 TR001863NCI NIH HHS P01 CA128814NCI NIH HHS P30 CA016359NCI NIH HHS P50 CA121974NCI NIH HHS R01 CA216846NCI NIH HHS R01 CA227473NCI NIH HHS R01 CA237586NIAMS NIH HHS T32 AR007016
Abstract
Tumours use various strategies to evade immune surveillance
Indexed as
Gene SilencingRetroelementsTumor EscapeAnimalsCell Line, TumorDNA-Binding ProteinsEpigenesis, GeneticHeterochromatinHistone-Lysine N-MethyltransferaseHumansInterferon Type IJumonji Domain-Containing Histone DemethylasesMaleMelanomaMiceMice, Inbred C57BLDNA-Binding ProteinsHeterochromatinHistone-Lysine N-MethyltransferaseInterferon Type IJumonji Domain-Containing Histone DemethylasesKDM5B protein, humanKdm5b protein, mouseNuclear ProteinsRepressor ProteinsRetroelementsSETDB1 protein, mouse
Identifiers
What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.