Evidence map›Paper›PMID 34671100›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2022

Association between anti-seizure medication and outcomes in infants.

Elizabeth K Sewell, Shannon E G Hamrick, Ravi M Patel, Monica Bennett, Veeral N Tolia, Kaashif A Ahmad

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Elizabeth K SewellDepartment of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, USA. elizabeth.sewell@emory.edu.ORCID http://orcid.org/0000-0003-3072-6569
Shannon E G HamrickDepartment of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, USA.
Ravi M PatelDepartment of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, USA.ORCID http://orcid.org/0000-0002-7444-5550
Monica BennettBaylor Scott and White Research Institute, Dallas, TX, USA.
Veeral N ToliaBaylor Scott and White Research Institute, Dallas, TX, USA.
Kaashif A AhmadDepartment of Pediatrics, Baylor College of Medicine, San Antonio, TX, USA.ORCID http://orcid.org/0000-0002-5970-6791
Emory University · USBaylor College of Medicine · USBaylor Medical Center at Garland · USBaylor University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare treatment failure between: (1) infants treated with phenobarbital versus levetiracetam for first-line treatment and (2) infants treated with phenytoin versus levetiracetam for second-line treatment following phenobarbital. STUDY

designThis retrospective cohort study included infants with seizures receiving phenobarbital or levetiracetam as the initial anti-seizure medication. Treatment failure was defined as the need for additional anti-seizure medication within 24-72 h and compared using mixed-effect logistic regression after adjustment for confounding factors, including center.

resultsIn this cohort of 6842 infants, the incidence of treatment failure was 31% vs. 38% in infants receiving first-line phenobarbital versus levetiracetam (adjusted OR: 0.70; 95% CI 0.58-0.84). There was no significant difference in second-line treatment failure (adjusted OR: 1.31; 95% CI 0.92-1.86).

conclusionsFirst-line treatment of neonatal seizures with phenobarbital is associated with a lower rate of treatment failure than levetiracetam. There was no significant difference in second-line treatment failure.

Indexed as

AnticonvulsantsPhenobarbitalHumansInfantInfant, NewbornLevetiracetamPhenytoinRetrospective StudiesAnticonvulsantsLevetiracetamPhenobarbitalPhenytoin

Identifiers

PMID34671100
OpenAlexW3206542063

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.