ArticleScientific reports2021
Triglycerides and low HDL cholesterol predict coronary heart disease risk in patients with stable angina.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Integrated Cardiac Imaging for the Detection and Characterization of Ischemic Heart Disease
"simulation modeling of coronary artery disease: a tool for clinical decision support"
Health Improvements by Understanding Residual Risk in CAd and NEw Targets for Prevention/treatment - HURRICANE
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Distinct Laboratory and Clinical Features of Metabolic and Alcohol-Related Liver Disease (MetALD): A Systematic Review and Meta-Analysis.Current obesity reports · 2026Pooled it
- Plasma lipidomics and coronary plaque changes: a substudy of the SMARTool clinical trial.European heart journal. Cardiovascular Imaging · 2024Trial
- Residual risk in atherosclerotic cardiovascular disease after statin therapy: Clinical mechanisms and management strategies.World journal of cardiology · 2026Review
- Triglycerides play a crucial role in the pathway from depression to cardiomyopathy: A mediation Mendelian randomization study.Medicine · 2026Article
- Triglycerides to high-density lipoprotein cholesterol ratio and its association with periodontitis-a systematic review.BDJ open · 2025Article
- PCSK9 and coronary atherosclerosis progression beyond LDL-cholesterol in coronary artery disease patients.European journal of clinical investigation · 2025Article
- Article
- Liposomal Delivery of Allolobophora caliginosa Coelomic Fluid Attenuates Myocardial Infarction by Suppressing Oxidative Damage, Inflammation, and Apoptosis.Applied biochemistry and biotechnology · 2025Article
- Vitamin D immune modulation of the anti-inflammatory effects of HDL-associated proteins.Lipids in health and disease · 2025Review
- Organic Trace Mineral Source Enhances the Bioavailability, Health Status, and Gut Microbiota Community in White Shrimp (Biology · 2025Article
- HDL-Cholesterol and Triglycerides Dynamics: Essential Players in Metabolic Syndrome.Antioxidants (Basel, Switzerland) · 2025Review
- Relationship Between Fasting Blood Glucose to High-Density Lipoprotein Cholesterol Ratio (GHR) and Coronary Artery Vascular Lesions: A Retrospective Cross-Sectional Study.International journal of general medicine · 2025Article
- Health improvements by understanding residual risk in coronary artery disease and new targets for prevention/treatment: rationale and research protocol of the HURRICANE project.European heart journal open · 2025Article
- Association Between Atherogenic Index of Plasma and Endometriosis: Evidence from NHANES 1999-2006.International journal of women's health · 2025Article
- Predicting the presence and severity of coronary artery disease using surrogate markers of insulin resistance: A cross-sectional study.ARYA atherosclerosis · 2025Article
- Dyslipidemia and associated factors among adult cardiac patients: a hospital-based comparative cross-sectional study.European journal of medical research · 2024Article
- Sex-based association between high-density lipoprotein cholesterol and adverse outcomes after coronary artery bypass grafting.BMC cardiovascular disorders · 2024Article
- Low HDL cholesterol and the eNOS Glu298Asp polymorphism are associated with inducible myocardial ischemia in patients with suspected stable coronary artery disease.BMC cardiovascular disorders · 2024Article
- Curcumin-rich curry consumption and life expectancy: Singapore longitudinal ageing study.GeroScience · 2024Article
- Analysis of Risk Factors and Construction of a Predictive Model for Readmission in Patients with Coronary Slow Flow Phenomenon.International journal of general medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We assessed whether high triglycerides (TG) and low high-density lipoprotein cholesterol (HDL-C) levels, expressed by an increased TG/HDL-C ratio, predict coronary atherosclerotic disease (CAD) outcomes in patients with stable angina. We studied 355 patients (60 ± 9 years, 211 males) with stable angina who underwent coronary computed tomography angiography (CTA), were managed clinically and followed for 4.5 ± 0.9 years. The primary composite outcome was all-cause mortality and non-fatal myocardial infarction. At baseline, the proportion of males, patients with metabolic syndrome, diabetes and obstructive CAD increased across TG/HDL-C ratio quartiles, together with markers of insulin resistance, hepatic and adipose tissue dysfunction and myocardial damage, with no difference in total cholesterol or LDL-C. At follow-up, the global CTA risk score (HR 1.06, 95% confidence interval (CI) 1.03-1.09, P = 0.001) and the IV quartile of the TG/HDL-C ratio (HR 2.85, 95% CI 1.30-6.26, P < 0.01) were the only independent predictors of the primary outcome. The TG/HDL-C ratio and the CTA risk score progressed over time despite increased use of lipid-lowering drugs and reduction in LDL-C. In patients with stable angina, high TG and low HDL-C levels are associated with CAD related outcomes independently of LDL-C and treatments.Trial registration. EVINCI study: ClinicalTrials.gov NCT00979199, registered September 17, 2009; SMARTool study: ClinicalTrials.gov NCT04448691, registered June 26, 2020.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.