ArticleScientific reports2021
Comparative of meibomian gland morphology in patients with evaporative dry eye disease versus non-dry eye disease.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Association of Eyelid Margin Thickness and Meibography in Dogs With Meibomian Gland Dysfunction.Veterinary ophthalmology · 2025Article
- Morphological Characteristics of the Meibomian Glands: Impact of Demographics and Contact Lens Wear.Translational vision science & technology · 2025Article
- Applied anatomy and morphology of Meibomian glands in the non-human primate.Scientific reports · 2025Article
- Meibomian gland atrophy in children with allergic conjunctivitis.International journal of ophthalmology · 2025Article
- A machine learning approach to predicting dry eye-related signs, symptoms and diagnoses from meibography images.Heliyon · 2024Article
- Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications.Smart molecules : open access · 2024Review
- Modeling dry eye with an air-liquid interface in corneal epithelium-on-a-chip.Scientific reports · 2024Article
- Automatic segmentation and quantified analysis of meibomian glands from infrared images.Indian journal of ophthalmology · 2023Observational
- Lacrimal and meibomian gland evaluation in dry eye disease: A mini-review.Indian journal of ophthalmology · 2023Review
- Morphologic variants of Meibomian glands: age-wise distribution and differences between upper and lower eyelids.Frontiers in medicine · 2023Article
- The efficacy of ocular surface assessment approaches in evaluating dry eye treatment with artificial tears.Scientific reports · 2022Article
- Predicting demographics from meibography using deep learning.Scientific reports · 2022Article
- Relationship between meibomian gland loss in infrared meibography and meibum quality in dry eye patients.BMC ophthalmology · 2022Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many recent studies have showed that morphological changes are one of the key signs of meibomian gland disease (MGD). These changes can be seen even before symptom onset, potentially underestimating the prevalence of MGD; however, until now, there is no conclusive information about the impact of meibomian gland (MG) morphology in tear film physiology and disease. This study aimed to investigate the prevalence of anatomical and morphological MG alterations between patients with evaporative dry eye disease (DED) and healthy controls. Retrospective chart review of seventy-five patients with evaporative DED and healthy individuals who had dry eye assessments included Ocular Surface Disease Index questionnaire, meibum quality, meibum expressibility, lid margin abnormality, ocular staining, non-invasive tear film break-up time, and meibography. We did not find significant differences in MG alterations in the upper lid between healthy and DED subjects. Patients with evaporative DED presented MG alterations in the lower lid more frequently than healthy subjects (54.8 vs. 30.3%; p = 0.03). The presence of shortened glands was the only MG alteration that was more prevalent in the lower lid in dry-eye patients than in healthy subjects (p < 0.05). Subjects with evaporative DED presented more alterations in the lower lid than healthy subjects.
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