ArticleEmerging infectious diseases2021
Multidrug-Resistant Methicillin-Resistant Staphylococcus aureus Associated with Bacteremia and Monocyte Evasion, Rio de Janeiro, Brazil.
Article in Emerging infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Methicillin-resistant Staphylococcus aureus.Nature reviews. Disease primers · 2026Review
- When First-Line Therapies Fail: Surgical Site Infections and the Declining Antimicrobial Utility in a Resource-Limited Nation.MicrobiologyOpen · 2026Article
- Phenotypic and genotypic antimicrobial resistance profiles of gram-positive cocci and non-fermenting gram-negative rods.Scientific reports · 2026Article
- Empowering global disease surveillance with CURED: a tool for rapid identification of unique genomic biomarkers.mSystems · 2026Article
- Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus Causing Healthcare-Associated Bloodstream Infections in Brazil: Results from A Prospective Countrywide Multicenter Study.Infectious diseases and therapy · 2026Article
- Emergence of ST3390: A Novel Apigmented MRSA Clone From the CC5 Lineage.The Journal of infectious diseases · 2026Article
- Mechanisms of action of the hexane extract ofADMET & DMPK · 2026Article
- Article
- Hospital-associated MRSA genotypes causing complicated community-onset skin and musculoskeletal infections.Frontiers in cellular and infection microbiology · 2025Article
- Decoding the evolutionary history of ST30Frontiers in microbiology · 2025Article
- Desiccation tolerance and reduced antibiotic resistance: Key drivers in ST239-III to ST22-IV MRSA clonal replacement at a Malaysian teaching hospital.International journal of medical microbiology : IJMM · 2024Article
- ST105 Lineage of MRSA: An Emerging Implication for Bloodstream Infection in the American and European Continents.Antibiotics (Basel, Switzerland) · 2024Review
- Different evolution ofHeliyon · 2024Article
- Regulation of σMicroorganisms · 2023Article
- Dynamics of the MRSA Population in a Chilean Hospital: a Phylogenomic Analysis (2000-2016).Microbiology spectrum · 2023Article
- Heavy Metal Pollution From a Major Earthquake and Tsunami in Chile Is Associated With Geographic Divergence of Clinical Isolates of Methicillin-ResistantbioRxiv : the preprint server for biology · 2023Article
- Genomic epidemiology ofMicrobial genomics · 2023Observational
- The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2020/2021.EFSA journal. European Food Safety Authority · 2023Article
- RdJ detection tests to identify a unique MRSA clone of ST105-SCCFrontiers in microbiology · 2023Article
- High frequency of increased triclosan MIC among CC5 MRSA and risk of misclassification of the SCCmec into types.The Journal of antimicrobial chemotherapy · 2022Article
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Authors and funding
18 authors at 6 institutions in 2 countries.
Funding
Abstract
We typed 600 methicillin-resistant Staphylococcus aureus (MRSA) isolates collected in 51 hospitals in the Rio de Janeiro, Brazil, metropolitan area during 2014-2017. We found that multiple new clonal complex (CC) 5 sequence types had replaced previously dominant MRSA lineages in hospitals. Whole-genome analysis of 208 isolates revealed an emerging sublineage of multidrug-resistant MRSA, sequence type 105, staphylococcal cassette chromosome mec II, spa t002, which we designated the Rio de Janeiro (RdJ) clone. Using molecular clock analysis, we hypothesized that this lineage began to expand in the Rio de Janeiro metropolitan area in 2009. Multivariate analysis supported an association between bloodstream infections and the CC5 lineage that includes the RdJ clone. Compared with other closely related isolates, representative isolates of the RdJ clone more effectively evaded immune function related to monocytic cells, as evidenced by decreased phagocytosis rate and increased numbers of viable unphagocytosed (free) bacteria after in vitro exposure to monocytes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.