ArticleEmerging infectious diseases2021
Genomic Profiling of Mycobacterium tuberculosis Strains, Myanmar.
Article in Emerging infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- A cloaked glutamate decarboxylase sustains the GABA shunt inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Molecular and Transmission Characteristics ofInfection and drug resistance · 2025Article
- Rifampicin resistantJournal of clinical tuberculosis and other mycobacterial diseases · 2024Article
- Genomic Sequencing Profiles ofTropical medicine and infectious disease · 2023Article
- First Detection of Mycobacterium tuberculosis Clinical Isolates Harboring I491F Borderline ResistanceAntimicrobial agents and chemotherapy · 2022Article
- Drug Resistance and Molecular Characteristics ofJournal of personalized medicine · 2022Article
- Distribution ofTropical medicine and infectious disease · 2022Article
- Drug-Resistant Characteristics, Genetic Diversity, and Transmission Dynamics of Rifampicin-Resistant Mycobacterium tuberculosis in Hunan, China, Revealed by Whole-Genome Sequencing.Microbiology spectrum · 2022Article
- The fourth national tuberculosis prevalence survey in Myanmar.PLOS global public health · 2022Article
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Authors and funding
10 authors.
Funding
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Abstract
Multidrug resistance is a major threat to global elimination of tuberculosis (TB). We performed phenotypic drug-susceptibility testing and whole-genome sequencing for 309 isolates from 342 consecutive patients who were given a diagnosis of TB in Yangon, Myanmar, during July 2016‒June 2018. We identified isolates by using the GeneXpert platform to evaluate drug-resistance profiles. A total of 191 (62%) of 309 isolates had rifampin resistance; 168 (88%) of these rifampin-resistant isolates were not genomically related, indicating the repeated emergence of resistance in the population, rather than extensive local transmission. We did not detect resistance mutations to new oral drugs, including bedaquiline and pretomanid. The current GeneXpert MTB/RIF system needs to be modified by using the newly launched Xpert MTB/XDR cartridge or line-probe assay. Introducing new oral drugs to replace those currently used in treatment regimens for multidrug-resistant TB will also be useful for treating TB in Myanmar.
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