Evidence map›Paper›PMID 34670548›Full record

ArticleBMC medical informatics and decision making2021

A statistical quality assessment method for longitudinal observations in electronic health record data with an application to the VA million veteran program.

Hui Wang, Ilana Belitskaya-Levy, Fan Wu, Jennifer S Lee, Mei-Chiung Shih, Philip S Tsao, Ying Lu, VA Million Veteran Program

Abstract read
In one paragraph

Article in BMC medical informatics and decision making, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Predicting post-liver transplant outcomes in patients with acute-on-chronic liver failure using Expert-Augmented Machine Learning.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023
    Article
  5. Article
  6. Optimization of the Electronic Health Record for Research.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2023
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hui WangDepartment of Veterans Affairs, Cooperative Studies Program Palo Alto Coordinating Center, 701B North Shoreline Blvd, Mountain View, CA, 94043, USA.
Ilana Belitskaya-LevyDepartment of Veterans Affairs, Cooperative Studies Program Palo Alto Coordinating Center, 701B North Shoreline Blvd, Mountain View, CA, 94043, USA.
Fan WuDepartment of Veterans Affairs, Cooperative Studies Program Palo Alto Coordinating Center, 701B North Shoreline Blvd, Mountain View, CA, 94043, USA.
Jennifer S LeeDepartment of Veterans Affairs, Cooperative Studies Program Palo Alto Coordinating Center, 701B North Shoreline Blvd, Mountain View, CA, 94043, USA.
Mei-Chiung ShihDepartment of Veterans Affairs, Cooperative Studies Program Palo Alto Coordinating Center, 701B North Shoreline Blvd, Mountain View, CA, 94043, USA.
Philip S TsaoDepartment of Veterans Affairs, Cooperative Studies Program Palo Alto Coordinating Center, 701B North Shoreline Blvd, Mountain View, CA, 94043, USA.
Ying LuDepartment of Veterans Affairs, Cooperative Studies Program Palo Alto Coordinating Center, 701B North Shoreline Blvd, Mountain View, CA, 94043, USA. ylu1@stanford.edu.
VA Million Veteran Program

Funding

Genetics of Cardiometabolic Diseases in the VA PopulationI01BX003362 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI Kyong-Mi Chang, Philip S Tsao · 2017 to 2026
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Efficient electronic phenotyping using APHRODITE in the Million Veteran ProgramI01HX002487 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI ASSIMES, THEMISTOCLES LEONARD, LEE, JENNIFER S · 2019 to 2021
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BLRD VA I01 BX003362HSRD VA I01 HX002487
6 · The paper itself

Abstract

backgroundTo describe an automated method for assessment of the plausibility of continuous variables collected in the electronic health record (EHR) data for real world evidence research use.

methodsThe most widely used approach in quality assessment (QA) for continuous variables is to detect the implausible numbers using prespecified thresholds. In augmentation to the thresholding method, we developed a score-based method that leverages the longitudinal characteristics of EHR data for detection of the observations inconsistent with the history of a patient. The method was applied to the height and weight data in the EHR from the Million Veteran Program Data from the Veteran's Healthcare Administration (VHA). A validation study was also conducted.

resultsThe receiver operating characteristic (ROC) metrics of the developed method outperforms the widely used thresholding method. It is also demonstrated that different quality assessment methods have a non-ignorable impact on the body mass index (BMI) classification calculated from height and weight data in the VHA's database.

conclusionsThe score-based method enables automated and scaled detection of the problematic data points in health care big data while allowing the investigators to select the high-quality data based on their need. Leveraging the longitudinal characteristics in EHR will significantly improve the QA performance.

Indexed as

Electronic Health RecordsVeteransBig DataData AccuracyData ManagementHumansClinical informaticsData quality assessment (DQA)Electronic health record (EHR)Health care big dataReal world evidenceVital signs

Identifiers

PMID34670548
PMCPMC8529838

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.