ArticleBMC cancer2021
Primary gross tumor volume is prognostic and suggests treatment in upper esophageal cancer.
Article in BMC cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Prognostic Value of a Novel Staging System Integrating Lymph Node Station Number and Tumor Regression Grade for Esophageal Cancer Following Neoadjuvant Chemoradiotherapy.Annals of surgical oncology · 2026Article
- Article
- Exploring the Role of LINC00115 in Esophageal Squamous Cell Carcinoma: Insights Into JAK1/STAT3 Pathway Activation and Metastatic Potential.JCO precision oncology · 2025Article
- Article
- Dose escalation in radical radio(chemo)therapy for cervical and upper thoracic esophageal cancer with 3DCRT/IMRT (ChC&UES): a multicenter retrospective study.Radiation oncology (London, England) · 2024Article
- Influence of age as a continuous variable on survival outcomes and treatment options in patients with upper thoracic esophageal carcinoma.Journal of Cancer · 2023Article
- Development of a prognostic nomogram and risk stratification system for upper thoracic esophageal squamous cell carcinoma.Frontiers in oncology · 2023Article
- A Study on Risk Factors Associated with Reflux Esophagitis in Patients Undergoing Esophageal Cancer Surgery.Journal of healthcare engineering · 2022Article
- The Prognostic Significance of Nomogram-Based Pretreatment Inflammatory Indicators in Patients With Esophageal Squamous Cell Carcinoma Receiving Intensity-Modulated Radiotherapy.Cancer control : journal of the Moffitt Cancer CenterArticle
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo aid clinicians strategizing treatment for upper esophageal squamous cell carcinoma (ESCC), this retrospective study investigated associations between primary gross tumor volume (GTVp) and prognosis in patients given surgical resection, radiotherapy, or both resection and radiotherapy.
methodsThe population comprised 568 patients with upper ESCC given definitive treatment, including 238, 216, and 114 who underwent surgery, radiotherapy, or combined radiotherapy and surgery. GTVp as a continuous variable was entered into the multivariate Cox model using penalized splines (P-splines) to determine the optimal cutoff value. Propensity score matching (PSM) was used to adjust imbalanced characteristics among the treatment groups.
resultsP-spline regression revealed a dependence of patient outcomes on GTVp, with 30 cm
conclusionGTVp is prognostic for OS and PFS in upper ESCC. For patients with GTVp ≥30 cm
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