Evidence map›Paper›PMID 34670510›Full record

ArticleBMC gastroenterology2021

Association between regular arrangement of collecting venules and Helicobacter pylori status in routine endoscopy.

Cong Yuan, Xue-Mei Lin, Yan Ou, Lin Cai, Qian Cheng, Ping Zhou, Juan Liao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Update on the pathogenesis and clinical management ofWorld journal of gastrointestinal pathophysiology · 2025
    Review
  2. Article
  3. Predicting Helicobacter pylori infection from endoscopic features.The Korean journal of internal medicine · 2024
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Cong Yuan *Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, Sichuan, China.ORCID http://orcid.org/0000-0002-1003-5819
Xue-Mei Lin *Department of Pathology, Basic Medical College of North Sichuan Medical College, Nanchong, 637000, Sichuan, China.
Yan OuDepartment of Gastroenterology, West China Forth Hospital, West China School of Public Health, Sichuan University, Chengdu, 610041, China.
Lin CaiDepartment of Gastroenterology, West China Forth Hospital, West China School of Public Health, Sichuan University, Chengdu, 610041, China.
Qian ChengDepartment of Gastroenterology, West China Forth Hospital, West China School of Public Health, Sichuan University, Chengdu, 610041, China.
Ping ZhouDepartment of Pathology, West China Forth Hospital, West China School of Public Health, Sichuan University, Chengdu, 610041, China.
Juan LiaoDepartment of Gastroenterology, West China Forth Hospital, West China School of Public Health, Sichuan University, Chengdu, 610041, China. juanliao@scu.edu.cn.ORCID http://orcid.org/0000-0002-2446-9861
Sichuan University · CNAffiliated Hospital of North Sichuan Medical College · CNNorth Sichuan Medical University · CN

Funding

International Cooperation Project of Sichuan Science and Technology Department 2020YFH0106
6 · The paper itself

Abstract

backgroundThe sensitivity of regular arrangement of collecting venules (RAC)-positive pattern for predicting Helicobacter pylori (H. pylori)-negative status greatly altered from 93.8 to 48.0% in recent two decades of various studies, while the reason behind it remained obscure. The aim of this study was to investigate the value of RAC as an endoscopic feature for judging H. pylori status in routine endoscopy and reviewed the underlying mechanism.

methodsA prospective study with high-definition non-magnifying endoscopy was performed. RAC-positive and RAC-negative patients were classified according to the collecting venules morphology of the lesser curvature in gastric corpus. Gastric biopsy specimens were obtained from the lesser and greater curvature of corpus with normal RAC-positive or abnormal RAC-negative mucosal patterns. Helicobacter pylori status was established by hematoxylin and eosin staining and immunohistochemistry.

results41 RAC-positive and 124 RAC-negative patients were enrolled from June 2020 to September 2020. The prevalence of H. pylori infection in patients with RAC-positive pattern and RAC-negative pattern was 7.3% (3/41) and 71.0% (88/124), respectively. Among all 124 RAC-negative patients, 36 (29.0%) patients were H. pylori-negative status. Ten patients (32.3%) demonstrated RAC-positive pattern in 31 H. pylori-eradicated cases. The sensitivity, specificity, positive predictive value, and negative predictive value of RAC-positive pattern for predicting H. pylori-negative status were 51.4% (95% CI, 0.395-0.630), 96.7% (95% CI, 0.900-0.991), 92.7% (95% CI, 0.790-0.981), and 71.0% (95% CI, 0.620-0.786), respectively.

conclusionsRAC presence can accurately rule out H. pylori infection of gastric corpus, and H. pylori-positive status cannot be predicted only by RAC absence in routine endoscopy. Trial registration The present study is a non-interventional trial.

Indexed as

GastritisHelicobacter pyloriGastric MucosaGastroscopyHumansProspective StudiesVenulesDigestive system diagnostic techniquesGastric mucosaGastrointestinal endoscopyHelicobacter pylori

Identifiers

PMID34670510
PMCPMC8527606
OpenAlexW3139421109

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.