Evidence map›Paper›PMID 34670331›Full record

ArticleBioorganic chemistry2021

Exploration of the 2,3-dihydroisoindole pharmacophore for inhibition of the influenza virus PA endonuclease.

Dominga Rogolino, Lieve Naesens, Jennifer Bartoli, Mauro Carcelli, Laura De Luca, Giorgio Pelosi, Ryjul W Stokes, Ria Van Berwaer, Serena Vittorio, Annelies Stevaert and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Pharmacophores of Influenza Virus PA Endonuclease Inhibitors.Advances in experimental medicine and biology · 2026
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Dominga RogolinoDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, and CIRCMSB (Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici) Parma Unit, 43124 Parma, Italy. Electronic address: dominga.rogolino@unipr.it.
Lieve NaesensRega Institute for Medical Research, KU Leuven - University of Leuven, B-3000 Leuven, Belgium. Electronic address: lieve.naesens@kuleuven.be.
Jennifer BartoliDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, and CIRCMSB (Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici) Parma Unit, 43124 Parma, Italy.
Mauro CarcelliDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, and CIRCMSB (Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici) Parma Unit, 43124 Parma, Italy.
Laura De LucaDipartimento di Scienze Chimiche, Biologiche, Farmaceutiche e Ambientali, Polo Universitario SS. Annunziata, Università di Messina, Viale Palatucci 13, Messina I-98168, Italy.
Giorgio PelosiDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, and CIRCMSB (Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici) Parma Unit, 43124 Parma, Italy.
Ryjul W StokesDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, United States.
Ria Van BerwaerRega Institute for Medical Research, KU Leuven - University of Leuven, B-3000 Leuven, Belgium.
Serena VittorioDipartimento di Scienze Chimiche, Biologiche, Farmaceutiche e Ambientali, Polo Universitario SS. Annunziata, Università di Messina, Viale Palatucci 13, Messina I-98168, Italy.
Annelies StevaertRega Institute for Medical Research, KU Leuven - University of Leuven, B-3000 Leuven, Belgium.
Seth M CohenDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, United States.
University of Parma · ITRega Institute for Medical Research · BEUniversity of California, San Diego · USUniversity of Messina · ITKU Leuven · BE

Funding

Metal-binding Isosteres for Influenza Endonuclease Inhibitors and BeyondR01AI149444 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SETH M COHEN · 2020 to 2026
$2.3M
NIAID NIH HHS R01 AI149444
6 · The paper itself

Abstract

Seasonal influenza A and B viruses represent a global concern. Antiviral drugs are crucial to treat severe influenza in high-risk patients and prevent virus spread in case of a pandemic. The emergence of viruses showing drug resistance, in particular for the recently licensed polymerase inhibitor baloxavir marboxil, drives the need for developing alternative antivirals. The endonuclease activity residing in the N-terminal domain of the polymerase acidic protein (PA

Indexed as

Antiviral AgentsDose-Response Relationship, DrugEnzyme InhibitorsHEK293 CellsHumansIsoindolesMolecular Docking SimulationMolecular StructureOrthomyxoviridaeRNA-Dependent RNA PolymeraseStructure-Activity RelationshipViral ProteinsAntiviral AgentsEnzyme InhibitorsIsoindolesPA protein, influenza virusesRNA-Dependent RNA PolymeraseViral ProteinsAntiviralEndonucleaseInfluenza virusIsoindolinoneMetal-binding pharmacophore

Identifiers

PMID34670331
PMCPMC8838982
OpenAlexW3202023523

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.