Evidence map›Paper›PMID 34670220›Full record

ArticleInternational archives of allergy and immunology2022

Detection of Salivary Tryptase Levels in Children following Oral Food Challenges.

Wouter W de Weger, Vibeke M Bruinenberg, Evelien M van der Lek, Jeroen H Gerrits, Lidy van Lente, Catherina E M Herpertz, Gerbrich N van der Meulen, Aline B Sprikkelman, Gerard H Koppelman, Arvid W A Kamps

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In one paragraph

Article in International archives of allergy and immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Wouter W de WegerDepartment of Paediatrics, Martini Hospital, Groningen, The Netherlands.
Vibeke M BruinenbergCerte, Department of Clinical Chemistry, Martini Hospital, Groningen, The Netherlands.
Evelien M van der LekDepartment of Paediatrics, Martini Hospital, Groningen, The Netherlands.
Jeroen H GerritsCerte, Department of Clinical Chemistry, Martini Hospital, Groningen, The Netherlands.
Lidy van LenteDepartment of Epidemiology, Martini Hospital, Groningen, The Netherlands.
Catherina E M HerpertzDepartment of Paediatrics, Martini Hospital, Groningen, The Netherlands.
Gerbrich N van der MeulenDepartment of Paediatrics, Martini Hospital, Groningen, The Netherlands.
Aline B SprikkelmanDepartment of Paediatric Pulmonology and Paediatric Allergology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Gerard H KoppelmanDepartment of Paediatric Pulmonology and Paediatric Allergology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Arvid W A KampsDepartment of Paediatrics, Martini Hospital, Groningen, The Netherlands.
Martini Ziekenhuis · NLUniversity Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOral food challenge (OFC) is commonly used to diagnose food allergy. This test is time and resource intensive, and conclusions are not always unequivocal as this relies on the interpretation of symptoms. Therefore, an objective marker would improve the accuracy of the diagnostic workup of food allergy.

objectivesThe aim of this study was to investigate whether tryptase can be detected in saliva of children following OFC.

methodChildren from 3 to 18 years of age were eligible for inclusion if an OFC for peanut or tree nut had been recommended. Saliva samples were collected prior to the first dose and 5, 10, and 15 min following the last administered dose during OFC. Assay precision, spike-and-recovery, and assessment of lower limit of detection of the tryptase immunoassay were examined before analysis of tryptase in saliva was performed.

resultsA total of 30 children were included (median age 8 years, 63.3% male, 53.3% positive OFC outcome). Tryptase was detected in saliva samples. The mean of the change in baseline tryptase value to each saliva collecting time point was significantly different in patients with a positive OFC outcome compared to a negative outcome (p < 0.01).

conclusionsThis study showed that tryptase can be detected in saliva of children following OFC. Increased levels of tryptase compared to baseline were found if the OFC outcome was positive, suggesting that measuring tryptase in saliva may be useful in the diagnosis of food allergy. Further research is needed to evaluate the potential association between tryptase levels and symptoms.

Indexed as

AllergensFood HypersensitivityArachisChildFemaleHumansMaleNutsTryptasesAllergensTryptasesAllergy and immunologyDiagnosisFood hypersensitivitySalivaTryptase

Identifiers

PMID34670220
PMCPMC8985013
OpenAlexW3207778773

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.