ArticlePLoS biology2021
RefPlantNLR is a comprehensive collection of experimentally validated plant disease resistance proteins from the NLR family.
Article in PLoS biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.
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102 citing papers in PubMed, 185 citations in OpenAlex.
- A broad-host-range Rhizobium rhizogenes strain enables transient expression across diverse crop species.PLoS biology · 2026Article
- A conserved small RNA-generating gene cluster undergoes sequence diversification and contributes to plant immunity.Nature communications · 2026Article
- Two atypical resistance proteins confer plant resistance to Melanaphis sorghi in sorghum.Plant communications · 2026Article
- Pangenome-resolved structural variation drives adaptation and trait evolution in cucumber.Nature genetics · 2026Article
- Machine learning empowers precise discovery of disease-resistance genes in plants.Plant physiology · 2026Article
- Contrasting evolutionary patterns of helper and sensor NRC NLRs in lettuce reflect functional divergence following subfunctionalization.PLoS genetics · 2026Article
- Article
- A potato late blight pathogen effector interacts with ENTH-domain protein TOL9a and an activated helper NLR to suppress immunity.Science advances · 2026Article
- Pan-NLRome analysis uncovers genetic diversity and evolutionary dynamics among rice, maize and sorghum.The plant genome · 2026Article
- A chromosome-level genome assembly of Solanum brevicaule (PI 473011) Y1-5, a wild potato relative with robust resistance to potato cyst nematodes.The plant genome · 2026Article
- Herbaria provide a valuable resource for obtaining informative mRNA.Genome research · 2026Article
- The Evolution and Origin of Allotetraploid Aegilops geniculata Revealed by the Homoeolog-Resolved Genome Assembly.Plant biotechnology journal · 2026Article
- A whole-genome assembly of St. Augustinegrass and visualizing diversity within the species.The plant genome · 2026Article
- NLRSeek: A reannotation-based pipeline for mining missing NLR genes in sequenced genomes.aBIOTECH · 2026Article
- Accelerating Resistance Breeding: Emerging Methods to Identify and Validate Plant Immunity Genes.Plants (Basel, Switzerland) · 2026Review
- Molecular mechanisms of plant NLR activation and signalling.The Plant journal : for cell and molecular biology · 2026Review
- Alternative splicing: an underexplored layer in immune receptor regulation, systemic resistance and priming.Frontiers in plant science · 2026Article
- Article
- Evolutionary histories of functional mutations during the domestication and spread ofProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Exploring fern pathosystems and immune receptors to bridge gaps in plant immunity.BMC biology · 2025Article
42 more citing papers are in PubMed but not listed here.
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4 authors at 1 institution in 1 country.
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Abstract
Reference datasets are critical in computational biology. They help define canonical biological features and are essential for benchmarking studies. Here, we describe a comprehensive reference dataset of experimentally validated plant nucleotide-binding leucine-rich repeat (NLR) immune receptors. RefPlantNLR consists of 481 NLRs from 31 genera belonging to 11 orders of flowering plants. This reference dataset has several applications. We used RefPlantNLR to determine the canonical features of functionally validated plant NLRs and to benchmark 5 NLR annotation tools. This revealed that although NLR annotation tools tend to retrieve the majority of NLRs, they frequently produce domain architectures that are inconsistent with the RefPlantNLR annotation. Guided by this analysis, we developed a new pipeline, NLRtracker, which extracts and annotates NLRs from protein or transcript files based on the core features found in the RefPlantNLR dataset. The RefPlantNLR dataset should also prove useful for guiding comparative analyses of NLRs across the wide spectrum of plant diversity and identifying understudied taxa. We hope that the RefPlantNLR resource will contribute to moving the field beyond a uniform view of NLR structure and function.
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