ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2022
Breathing rate variability in obstructive sleep apnea during wakefulness.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Respiratory signal extraction from the electrocardiogram for risk stratification in cardiac patients.European heart journal. Digital health · 2026Review
- Dysfunctional breathing in patients with moderate and severe obstructive sleep apnea: a cross sectional study.Sleep & breathing = Schlaf & Atmung · 2026Article
- Association of Interictal Respiratory Variability and Severity of Postictal Hypoxemia After Generalized Convulsive Seizures.Neurology · 2026Article
- Obstructive Sleep Apnea Syndrome and Ischemic Stroke: Investigating Inflammatory Mechanisms.Nature and science of sleep · 2026Review
- Sleep-Disordered Breathing and Clinical Presentation in Infants with Congenital Laryngomalacia: A Polysomnographic Study.Journal of clinical medicine · 2025Article
- Canary in the Coalmine?: Breathing Dynamics and Cognitive Performance in the Hispanic Community Health Study/Study of Latinos.CHEST pulmonary · 2025Article
- Sleep Parameters of Breathing and Cognitive Function in a Diverse Hispanic/Latino Cohort.CHEST pulmonary · 2025Article
- Assessment of sleep patterns in dementia and general population cohorts using passive in-home monitoring technologies.Communications medicine · 2024Article
- Role of Nasal Surgery in Adult Obstructive Sleep Apnea: A Systematic Review.Sleep science (Sao Paulo, Brazil) · 2024Review
- Novel Metric for Non-Invasive Beat-to-Beat Blood Pressure Measurements Demonstrates Physiological Blood Pressure Fluctuations during Pregnancy.Sensors (Basel, Switzerland) · 2024Article
- Interictal respiratory variability predicts severity of hypoxemia after generalized convulsive seizures.Epilepsia · 2023Article
- Temporal Feature Extraction and Machine Learning for Classification of Sleep Stages Using Telemetry Polysomnography.Brain sciences · 2023Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
STUDY
objectivesObstructive sleep apnea (OSA) is defined by pauses in breathing during sleep, but daytime breathing dysregulation may also be present. Sleep may unmask breathing instability in OSA that is usually masked by behavioral influences during wakefulness. A breath-hold (BH) challenge has been used to demonstrate breathing instability. One measure of breathing stability is breathing rate variability (BRV). We aimed to assess BRV during rest and in response to BH in OSA.
methodsWe studied 62 participants (31 with untreated OSA: respiratory event index [mean ± SD] 20 ± 15 events/h, 12 females, age 51 ± 14 years, body mass index [BMI] 32 ± 8 kg/m
resultsWe found 10% higher BRV in OSA vs controls (
conclusionsThe findings suggest breathing instability as reflected by BRV is high in OSA during wakefulness, both at rest and in response to a stimulus. Breathing instability together with high blood pressure variability in OSA may reflect a compromised cardiorespiratory consequence in OSA during wakefulness. CITATION: Pal A, Martinez F, Akey MA, et al. Breathing rate variability in obstructive sleep apnea during wakefulness.
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Registered trials
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