ArticleJournal of neurophysiology2021
Intrinsic brainstem circuits comprised of Chx10-expressing neurons contribute to reticulospinal output in mice.
Article in Journal of neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Similarities betweeneNeuro · 2026Article
- Synergistic mechanisms of medullary cholinergic-serotonergic pathway interactions in regulating neuronal excitability and locomotor activities.Communications biology · 2025Article
- From thought to action: The organization of spinal projecting neurons.Cell reports · 2025Review
- The dorsal/ventral subdivision of the hindbrain predates the tunicate/vertebrate split.bioRxiv : the preprint server for biology · 2025Article
- Motor neurons in the tunicate caudal central nervous system reveal homology to the vertebrate spinal cord.Development (Cambridge, England) · 2025Article
- Bradykinesia and postural instability in a model of prodromal synucleinopathy with α-synuclein aggregation initiated in the gigantocellular nuclei.Acta neuropathologica communications · 2025Article
- Functional plasticity of glutamatergic neurons of medullary reticular nuclei after spinal cord injury in mice.Nature communications · 2024Article
- Hodological patterning as an organizing principle in vertebrate motor circuitry.Frontiers in neuroanatomy · 2024Review
- Article
- The mesencephalic locomotor region recruits V2a reticulospinal neurons to drive forward locomotion in larval zebrafish.Nature neuroscience · 2023Article
- Chx10+V2a interneurons in spinal motor regulation and spinal cord injury.Neural regeneration research · 2023Review
- Lumbar V3 interneurons provide direct excitatory synaptic input onto thoracic sympathetic preganglionic neurons, linking locomotor, and autonomic spinal systems.Frontiers in neural circuits · 2023Article
- Networking brainstem and basal ganglia circuits for movement.Nature reviews. Neuroscience · 2022Review
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Glutamatergic reticulospinal neurons in the gigantocellular reticular nucleus (GRN) of the medullary reticular formation can function as command neurons, transmitting motor commands to spinal cord circuits to instruct movement. Recent advances in our understanding of this neuron-dense region have been facilitated by the discovery of expression of the transcriptional regulator, Chx10, in excitatory reticulospinal neurons. Here, we address the capacity of local circuitry in the GRN to contribute to reticulospinal output. We define two subpopulations of Chx10-expressing neurons in this region, based on distinct electrophysiological properties and soma size (small and large), and show that these populations correspond to local interneurons and reticulospinal neurons, respectively. Using focal release of caged glutamate combined with patch clamp recordings, we demonstrated that Chx10 neurons form microcircuits in which the Chx10 local interneurons project to and facilitate the firing of Chx10 reticulospinal neurons. We discuss the implications of these microcircuits in terms of movement selection.
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