ArticleScience advances2021
Disrupted circadian oscillations in type 2 diabetes are linked to altered rhythmic mitochondrial metabolism in skeletal muscle.
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Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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70citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
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Who cites it
70 citing papers in PubMed, 111 citations in OpenAlex.
- Morning exercise and pre-breakfast metformin interact to reduce glycaemia in people with type 2 diabetes: a randomized crossover trial.The Journal of physiology · 2024Trial
- Stable clocks, rewired rhythms: circadian remodeling in skeletal muscle during aging, cachexia, and type 2 diabetes.Life metabolism · 2026Review
- Restoration of circadian rhythm as novel targets against sarcopenia.Chinese medical journal · 2026Review
- Nocturnal fat oxidation is lower in older individuals with overweight/obesity, including those with type 2 diabetes, and is associated with fasting triglyceride levels.Diabetologia · 2026Article
- Chrono-Exercise Medicine: Why Biological Timing Matters for Human Health.Biomedicines · 2026Article
- Circadian biology and exercise: the time to move.Life metabolism · 2026Review
- Mitochondrial cristae density is increased following high-intensity interval training in men with type 2 diabetes.Diabetologia · 2026Article
- Co-expression network analysis reveals repression ofbioRxiv : the preprint server for biology · 2026Article
- Exercise Timing in Sport: Molecular and Physiological Mechanisms Linking Performance, Recovery, and Biological Cost.International journal of molecular sciences · 2026Review
- Impacts of exercise, renin-angiotensin system modulation or both on skeletal muscle circadian gene expression.Experimental physiology · 2026Article
- Disrupted renal clock and blood pressure rhythms in type 2 diabetic nephropathy.Clinical science (London, England : 1979) · 2026Article
- The interplay between circadian rhythm components and apoptosis in health and disease.Human cell · 2026Review
- Timing of exercise differentially modulates fear memory and hippocampal neurotransmitters in male rats.Frontiers in neuroscience · 2026Article
- Nutritional adaptation to circadian misalignment: implications for musculoskeletal health in modern lifestyles.Frontiers in nutrition · 2026Review
- Skeletal muscle atrophy and dysfunction in obesity and type-2 diabetes mellitus: Myocellular mechanisms involved.Reviews in endocrine & metabolic disorders · 2025Review
- Time to Reset: The Interplay Between Circadian Rhythms and Redox Homeostasis in Skeletal Muscle Ageing and Systemic Health.Antioxidants (Basel, Switzerland) · 2025Review
- The intricate link between circadian rhythms and aging: can resetting our circadian clock hold the key to longevity?Biogerontology · 2025Review
- Live-cell GLUT4 translocation assay reveals Per3 as a novel regulator of circadian insulin sensitivity in skeletal muscle cells.Biology open · 2025Article
- Down-regulation of human-specific lncRNA TMEM9B-AS1 in skeletal muscle of people with type 2 diabetes affects ribosomal biogenesis.Science advances · 2025Article
- Role of circadian rhythms in heart failure: insights from myocardial energy metabolism.Journal of translational medicine · 2025Review
10 more citing papers are in PubMed but not listed here.
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Authors and funding
20 authors at 5 institutions in 5 countries.
Brendan M GabrielDepartment of Physiology and Pharmacology, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-6878-8779
Ali AltıntaşNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-8932-0160
Jonathon A B SmithDepartment of Physiology and Pharmacology, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-2452-1655
Laura Sardon-PuigDepartment of Molecular Medicine and Surgery, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.
Xiping ZhangDepartment of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, FL, USA.ORCID 0000-0003-3202-451X
Astrid L BasseNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-6532-9232
Rhianna C LakerNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-0507-7838
Hui GaoDepartment of Biosciences and Nutrition (BioNut), Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-7306-7471
Zhengye LiuDepartment of Physiology and Pharmacology, Molecular Muscle Physiology and Pathophysiology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-7054-6151
Lucile DolletDepartment of Physiology and Pharmacology, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.
Jonas T TreebakNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-1488-7012
Antonio ZorzanoInstitute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID 0000-0002-1638-0306
Zhiguang HuoDepartment of Biostatistics, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-8032-4392
Mikael RydénDepartment of Medicine (H7), Unit for Endocrinology and Diabetes, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-4785-1876
Johanna T LannerDepartment of Physiology and Pharmacology, Molecular Muscle Physiology and Pathophysiology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-1222-9473
Karyn A EsserDepartment of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-5791-1441
Romain BarrèsNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-0158-519X
Nicolas J PillonDepartment of Physiology and Pharmacology, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-1107-9490
Anna KrookDepartment of Physiology and Pharmacology, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-0891-0258
Juleen R ZierathDepartment of Physiology and Pharmacology, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-6891-7497
Karolinska Institutet · SEUniversity of Copenhagen · DKUniversity of Florida · USInstituto de Salud Carlos III · ESUniversity of Aberdeen · GB
Funding
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8MMuscle clock and weakness: diversity supplementR01AR079220 · NIAMS · UNIVERSITY OF FLORIDA · PI ESSER, KARYN A · 2021 to 2025
$2.8MMuscle clock disruption accelerates the onset and progression of neurodegenerationR01AR066082 · NIAMS · UNIVERSITY OF KENTUCKY · PI ESSER, KARYN A · 2014 to 2018
$2.0MNIAMS NIH HHS R01 AR066082NIAMS NIH HHS R01 AR079220NIA NIH HHS P30 AG028740
Abstract
Circadian rhythms are generated by an autoregulatory feedback loop of transcriptional activators and repressors. Circadian rhythm disruption contributes to type 2 diabetes (T2D) pathogenesis. We elucidated whether altered circadian rhythmicity of clock genes is associated with metabolic dysfunction in T2D. Transcriptional cycling of core-clock genes
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.