ArticleScience advances2021
A macroecological description of alternative stable states reproduces intra- and inter-host variability of gut microbiome.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Eco-evolutionary dynamics lead to functionally robust and redundant communities.PLoS computational biology · 2026Article
- Article
- Host traits and environmental factors shape infection heterogeneity in wild rat-protozoa networks.ISME communications · 2026Article
- Macroecological Laws Can Naturally Arise from Chaotic Internal Species Dynamics.bioRxiv : the preprint server for biology · 2025Article
- Variance in C. elegans gut bacterial load suggests complex host-microbe dynamics.PLoS computational biology · 2025Article
- Resilience of a stochastic generalized Lotka-Volterra model for microbiome studies.Mathematical biosciences and engineering : MBE · 2025Article
- Macroecological patterns in experimental microbial communities.PLoS computational biology · 2025Article
- Linking energetic instability to compositional changes in biological communities.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dynamic coexistence driven by physiological transitions in microbial communities.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Emergence of alternative stable states in microbial communities undergoing horizontal gene transfer.eLife · 2025Article
- Growth-rate distributions of gut microbiota time series.Scientific reports · 2025Article
- Fecal microbiota transplants facilitate post-antibiotic recovery of gut microbiota in cheetahs (Acinonyx jubatus).Communications biology · 2024Article
- Inferring stability and persistence in the vaginal microbiome: A stochastic model of ecological dynamics.Research square · 2024Article
- Inferring stability and persistence in the vaginal microbiome: A stochastic model of ecological dynamics.bioRxiv : the preprint server for biology · 2024Article
- Model-free prediction of microbiome compositions.Microbiome · 2024Article
- Sparse species interactions reproduce abundance correlation patterns in microbial communities.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Emergent Functional Organization of Gut Microbiomes in Health and Diseases.Biomolecules · 2023Article
- Article
- Growth phase estimation for abundant bacterial populations sampled longitudinally from human stool metagenomes.Nature communications · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The most fundamental questions in microbial ecology concern the diversity and variability of communities. Their composition varies widely across space and time, as a result of a nontrivial combination of stochastic and deterministic processes. The interplay between nonlinear community dynamics and environmental fluctuations determines the rich statistical structure of community variability. We analyze long time series of individual human gut microbiomes and compare intra- and intercommunity dissimilarity under a macroecological framework. We show that most taxa have large but stationary fluctuations over time, while a minority of taxa display rapid changes in average abundance that cluster in time, suggesting the presence of alternative stable states. We disentangle interindividual variability in a stochastic component and a deterministic one, the latter recapitulated by differences in carrying capacities. Last, by combining environmental fluctuations and alternative stable states, we introduce a model that quantitatively predicts the statistical properties of both intra- and interindividual community variability, therefore summarizing variation in a unique macroecological framework.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.