Evidence map›Paper›PMID 34669471›Full record

ArticleScience advances2021

Complex 3D microfluidic architectures formed by mechanically guided compressive buckling.

Haiwen Luan, Qihui Zhang, Tzu-Li Liu, Xueju Wang, Shiwei Zhao, Heling Wang, Shenglian Yao, Yeguang Xue, Jean Won Kwak, Wubin Bai and 17 more

Abstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Liquid Metals for Reconfigurable Bioelectronics.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Engineering Organ-on-a-Chip Systems for Vascular Diseases.Arteriosclerosis, thrombosis, and vascular biology · 2023
    Review
  13. A wireless, battery-free device enables oxygen generation and immune protection of therapeutic xenotransplants in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  14. Review
  15. Article
  16. Type-Independent 3D Writing and Nano-Patterning of Confined Biopolymers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Haiwen LuanQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-0722-1108
Qihui ZhangQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Tzu-Li LiuQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Xueju WangDepartment of Materials Science and Engineering, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0002-0669-8759
Shiwei ZhaoDepartment of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-9797-1334
Heling WangDepartment of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0001-7859-5153
Shenglian YaoQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Yeguang XueDepartment of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-1968-5092
Jean Won KwakQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0001-7883-9242
Wubin BaiQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-2872-5559
Yameng XuDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.
Mengdi HanQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Kan LiDepartment of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-4864-3446
Zhengwei LiQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Xinchen NiQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-3327-3764
Jilong YeDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.
Dongwhi ChoiDepartment of Mechanical Engineering (Integrated Engineering Program), Kyung Hee University, Yongin, Gyeonggi 17104, Republic of Korea.ORCID 0000-0002-9286-2710
Quansan YangQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0001-8029-1327
Jae-Hwan KimQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-8940-652X
Shuo LiQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-4913-730X
Shulin ChenDepartment of Materials Science and Engineering, Ohio State University, Columbus, OH 43210, USA.
Changsheng WuQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Di LuQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Jan-Kai ChangQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-3056-1250
Zhaoqian XieState Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian, Liaoning 116024, China.ORCID 0000-0003-1320-817X
Yonggang HuangQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-0483-8359
John A RogersQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-3830-5980

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microfluidic technologies have wide-ranging applications in chemical analysis systems, drug delivery platforms, and artificial vascular networks. This latter area is particularly relevant to 3D cell cultures, engineered tissues, and artificial organs, where volumetric capabilities in fluid distribution are essential. Existing schemes for fabricating 3D microfluidic structures are constrained in realizing desired layout designs, producing physiologically relevant microvascular structures, and/or integrating active electronic/optoelectronic/microelectromechanical components for sensing and actuation. This paper presents a guided assembly approach that bypasses these limitations to yield complex 3D microvascular structures from 2D precursors that exploit the full sophistication of 2D fabrication methods. The capabilities extend to feature sizes <5 μm, in extended arrays and with various embedded sensors and actuators, across wide ranges of overall dimensions, in a parallel, high-throughput process. Examples include 3D microvascular networks with sophisticated layouts, deterministically designed and constructed to expand the geometries and operating features of artificial vascular networks.

Identifiers

PMID34669471
PMCPMC8528415

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.