ArticleScience advances2021
Capturing an elusive but critical element: Natural protein enables actinium chemistry.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The trial behind it
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Who cites it
15 citing papers in PubMed.
- Expanding on the ability of trivalent actinides to support microbial alcohol metabolism in evolved methylotrophic bacterium.Communications chemistry · 2025Article
- Computationally derived structural insights into Rare Earth selectivity in lanmodulin and its variants.Computational and structural biotechnology journal · 2025Article
- Biogeochemistry of Actinides: Recent Progress and Perspective.ACS environmental Au · 2024Review
- Actinium chelation and crystallization in a macromolecular scaffold.Nature communications · 2024Article
- Rare earth elements in biology: From biochemical curiosity to solutions for extractive industries.Microbial biotechnology · 2024Review
- Lanmodulin's EF 2-3 Domain: Insights from Infrared Spectroscopy and Simulations.ACS chemical biology · 2024Article
- Radiochemistry: A Hot Field with Opportunities for Cool Chemistry.ACS central science · 2023Review
- Recent Innovations and Nano-Delivery of Actinium-225: A Narrative Review.Pharmaceutics · 2023Review
- Radiolabeling andRSC chemical biology · 2023Article
- Article
- The elements of life: A biocentric tour of the periodic table.Advances in microbial physiology · 2023Article
- A genetically encoded fluorescent sensor for manganese(II), engineered from lanmodulin.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Lanmodulin peptides - unravelling the binding of the EF-Hand loop sequences stripped from the structural corset.Inorganic chemistry frontiers · 2022Article
- Engineering lanmodulin's selectivity for actinides over lanthanides by controlling solvent coordination and second-sphere interactions.Chemical science · 2022Article
- Americium preferred: lanmodulin, a natural lanthanide-binding protein favors an actinide over lanthanides.Chemical science · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Actinium-based therapies could revolutionize cancer medicine but remain tantalizing due to the difficulties in studying and limited knowledge of Ac chemistry. Current efforts focus on small synthetic chelators, limiting radioisotope complexation and purification efficiencies. Here, we demonstrate a straightforward strategy to purify medically relevant radiometals, actinium(III) and yttrium(III), and probe their chemistry, using the recently discovered protein, lanmodulin. The stoichiometry, solution behavior, and formation constant of the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.