Evidence map›Paper›PMID 34669441›Full record

ArticleScience translational medicine2021

A rapid assay provides on-site quantification of tetrahydrocannabinol in oral fluid.

Hojeong Yu, Hoyeon Lee, Jiyong Cheong, Sang Won Woo, Juhyun Oh, Hyun-Kyung Oh, Jae-Hyun Lee, Hui Zheng, Cesar M Castro, Yeong-Eun Yoo and 4 more

Abstract read
In one paragraph

Article in Science translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hojeong YuCenter for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA 02114, USA.ORCID 0000-0002-9264-8503
Hoyeon LeeDepartment of Chemistry, School of Physics and Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, South Korea.ORCID 0000-0001-9658-0465
Jiyong CheongCenter for Nanomedicine, Institute for Basic Science (IBS), Seoul 03722, South Korea.ORCID 0000-0001-6652-9394
Sang Won WooDepartment of Nano Manufacturing Technology, Korea Institute of Machinery and Materials, Daejeon 34103, South Korea.
Juhyun OhCenter for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA 02114, USA.ORCID 0000-0002-4492-6978
Hyun-Kyung OhDepartment of Chemistry, School of Physics and Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, South Korea.
Jae-Hyun LeeCenter for Nanomedicine, Institute for Basic Science (IBS), Seoul 03722, South Korea.
Hui ZhengBiostatistics Center, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0001-6725-1910
Cesar M CastroCenter for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA 02114, USA.ORCID 0000-0002-1159-5658
Yeong-Eun YooDepartment of Nano Manufacturing Technology, Korea Institute of Machinery and Materials, Daejeon 34103, South Korea.ORCID 0000-0003-4941-2121
Min-Gon KimDepartment of Chemistry, School of Physics and Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, South Korea.
Jinwoo CheonCenter for Nanomedicine, Institute for Basic Science (IBS), Seoul 03722, South Korea.ORCID 0000-0001-8948-5929
Ralph WeisslederCenter for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA 02114, USA.ORCID 0000-0003-0828-4143
Hakho LeeCenter for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA 02114, USA.ORCID 0000-0002-0087-0909

Funding

Early Detection through Novel OCEAN Technology - Ovarian Cancer Exosomal Analysis with NanoplasmonicsU01CA233360 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CASTRO, CESAR M, DINULESCU, DANIELA M · 2018 to 2022
$3.5M
Clinical platform for high-throughput analyses of extracellular vesiclesR01CA229777 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, HAKHO, SKOG, JOHAN · 2018 to 2022
$3.2M
Imaging and Liquid Biopsy for Glioma Diagnosis and Treatment MonitoringR01CA239078 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BALAJ, LEONORA, LEE, HAKHO · 2020 to 2024
$3.1M
Standardized Molecular Analyses of Glioma EVsR01CA237500 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CARTER, BOB S, LEE, HAKHO · 2020 to 2024
$3.0M
High throughput nanoplasmonic exosome testing (NEXT) of immunotherapies in bladder cancerR01CA264363 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CASTRO, CESAR M, LEE, HAKHO · 2021 to 2024
$2.4M
Multiplexed analysis of exosomes in cancer nano therapyR01CA204019 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2016 to 2020
$1.9M
High-throughput Integrated Magneto-electrochemical Exosome (HiMEX) platform to identify neurodevelopmental markers associated with pre and postnatal oxycodone exposureR21DA049577 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, HAKHO, PENDYALA, GURUDUTT · 2019 to 2020
$458k
NCI NIH HHS R01 CA204019NCI NIH HHS R01 CA229777NCI NIH HHS R01 CA237500NCI NIH HHS R01 CA239078NCI NIH HHS R01 CA264363NCI NIH HHS U01 CA233360NIDA NIH HHS R21 DA049577
6 · The paper itself

Abstract

Tetrahydrocannabinol (THC), the primary psychoactive ingredient of cannabis, impairs cognitive and motor function in a concentration-dependent fashion. Drug testing is commonly performed for employment and law enforcement purposes; however, available tests produce low-sensitive binary results (lateral flow assays) or have long turnaround (gas chromatography–mass spectrometry). To enable on-site THC quantification in minutes, we developed a rapid assay for oral THC analysis called EPOCH (express probe for on-site cannabis inhalation). EPOCH features distinctive sensor design such as a radial membrane and transmission optics, all contained in a compact cartridge. This integrated approach permitted assay completion within 5 min with a detection limit of 0.17 ng/ml THC, which is below the regulatory guideline (1 ng/ml). As a proof of concept for field testing, we applied EPOCH to assess oral fluid samples from cannabis users (

Indexed as

DronabinolSubstance Abuse DetectionBiological AssaySalivaTandem Mass SpectrometryDronabinol

Identifiers

PMID34669441
PMCPMC9126021

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.