Evidence map›Paper›PMID 34669040›Full record

ReviewCurrent topics in microbiology and immunology2024

The Controlled Human Infection Model for Enterotoxigenic Escherichia coli.

Chad K Porter, Kawsar R Talaat, Sandra D Isidean, Alwine Kardinaal, Subhra Chakraborty, Ramiro L Gutiérrez, David A Sack, A Louis Bourgeois

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current topics in microbiology and immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Flagellar regulation in enterotoxigenicInfection and immunity · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chad K PorterEnteric Diseases Department, Naval Medical Research Center, Silver Spring, MD, 20910, USA. chad.k.porter2.civ@mail.mil.ORCID http://orcid.org/0000-0001-7258-1690
Kawsar R TalaatCenter for Immunization Research, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA.ORCID http://orcid.org/0000-0002-4899-6260
Sandra D IsideanEnteric Diseases Department, Naval Medical Research Center, Silver Spring, MD, 20910, USA.ORCID http://orcid.org/0000-0003-1177-2316
Alwine KardinaalNIZO Food Research, Ede, P.O. Box 20, 6710 BA EDE, Kernhemseweg 2, 6718 ZB EDE, The Netherlands.ORCID http://orcid.org/0000-0002-2331-2264
Subhra ChakrabortyDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA.ORCID http://orcid.org/0000-0002-9188-6796
Ramiro L GutiérrezEnteric Diseases Department, Naval Medical Research Center, Silver Spring, MD, 20910, USA.ORCID http://orcid.org/0000-0001-6950-1370
David A SackDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA.ORCID http://orcid.org/0000-0002-9338-5119
A Louis BourgeoisPATH|Center for Vaccine Innovation and Access, 455 Massachusetts Avenue NW, Suite 1000, Washington, DC, 20001, USA.ORCID http://orcid.org/0000-0001-8952-5302

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The controlled human infection model (CHIM) for enterotoxigenic Escherichia coli (ETEC) has been instrumental in defining ETEC as a causative agent of acute watery diarrhea, providing insights into disease pathogenesis and resistance to illness, and enabling preliminary efficacy evaluations for numerous products including vaccines, immunoprophylactics, and drugs. Over a dozen strains have been evaluated to date, with a spectrum of clinical signs and symptoms that appear to replicate the clinical illness seen with naturally occurring ETEC. Recent advancements in the ETEC CHIM have enhanced the characterization of clinical, immunological, and microbiological outcomes. It is anticipated that omics-based technologies applied to ETEC CHIMs will continue to broaden our understanding of host-pathogen interactions and facilitate the development of primary and secondary prevention strategies.

Indexed as

Enterotoxigenic Escherichia coliEscherichia coli InfectionsAnimalsDiarrheaEscherichia coli VaccinesHost-Pathogen InteractionsHumansEscherichia coli VaccinesCHIMClinical trialControlled human infection modelDiarrheaEnterotoxigenic Escherichia coli; ETECExperimental infectionTravelers’ diarrheaVaccine

Identifiers

PMID34669040

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.