ReviewAnalytical and bioanalytical chemistry2022
The role of Raman spectroscopy in biopharmaceuticals from development to manufacturing.
Review in Analytical and bioanalytical chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- Raman-guided sample subset selection for cost-efficient offline calibration in bioprocesses.Bioprocess and biosystems engineering · 2026Article
- Hand-Held Raman Spectroscopy for Paracetamol Assay in Solution for Infusion: Expanding the Capabilities of Process Analytical Technologies.The AAPS journal · 2026Article
- Raman Spectroscopy for Characterizing Monoclonal Antibody Reduction: A Process Analytical Technology Approach for Antibody-Drug Conjugation Process Development.Pharmaceutical research · 2026Article
- Raman spectral unmixing for quantitative analysis of multicomponent amino acid mixtures.Analytical and bioanalytical chemistry · 2026Article
- Variable-specific preprocessing enables cross-scale transferable Raman models from high-throughput bioreactor data.Bioresources and bioprocessing · 2026Article
- Applying Raman Spectroscopy for Real-Time Monitoring of Ultra- and Diafiltration Steps in Viral Vector Purification.Pharmaceutics · 2026Article
- Operationalizing digital twins in biomanufacturing through interoperable process analytical technology.Bioprocess and biosystems engineering · 2026Article
- Online Raman spectroscopy-guided strategy for efficient production of DNA recombinase UvsX in Escherichia coli.Analytical and bioanalytical chemistry · 2026Article
- Spectroscopy-Based Cell Culture Predictive Monitoring.Biotech (Basel (Switzerland)) · 2026Article
- Selecting Raman spectra filtering based on an exhaustive statistical approach for inline bioprocesses monitoring using Sf9 insect cells.Bioprocess and biosystems engineering · 2026Article
- A Review on Quantitative Process Analytical Technology for Continuous Downstream Processing of Monoclonal Antibodies.Biotechnology and bioengineering · 2026Review
- Optical imaging and spectroscopic characterization of subvisible particles in protein therapeutics.Advanced drug delivery reviews · 2026Review
- Towards Rapid Calibration of Bioprocess Quantification Models Using Single Compound Raman Spectra: A Comparison of Four Approaches.Biotechnology and bioengineering · 2026Article
- Raman spectroscopy enables non-destructive quantification of nitrate in C3 and C4 plants.Frontiers in plant science · 2026Article
- AI-enabled fungal biomanufacturing: from genome mining to the artificial intelligence virtual cell.Mycology · 2026Review
- Biopharmaceutical analysis - current analytical challenges, limitations, and perspectives.Analytical and bioanalytical chemistry · 2026Review
- Raman imaging of molecular groups in the wavenumber silent region.Analytical and bioanalytical chemistry · 2026Review
- Clip-on adapter for simultaneous inline Raman and fluorescence spectroscopy inside semitransparent plastic pipes.Analytical and bioanalytical chemistry · 2026Article
- Surface enhanced Raman spectroscopy and machine learning as an accurate and rapid diagnostic tool for hydrocephalus.Scientific reports · 2025Article
- Noninvasive monitoring and prediction of cell count of Saccharomyces suspensions using ultrasonic measurements and artificial neural networks.Analytical and bioanalytical chemistry · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biopharmaceuticals have revolutionized the field of medicine in the types of active ingredient molecules and treatable indications. Adoption of Quality by Design and Process Analytical Technology (PAT) frameworks has helped the biopharmaceutical field to realize consistent product quality, process intensification, and real-time control. As part of the PAT strategy, Raman spectroscopy offers many benefits and is used successfully in bioprocessing from single-cell analysis to cGMP process control. Since first introduced in 2011 for industrial bioprocessing applications, Raman has become a first-choice PAT for monitoring and controlling upstream bioprocesses because it facilitates advanced process control and enables consistent process quality. This paper will discuss new frontiers in extending these successes in upstream from scale-down to commercial manufacturing. New reports concerning the use of Raman spectroscopy in the basic science of single cells and downstream process monitoring illustrate industrial recognition of Raman's value throughout a biopharmaceutical product's lifecycle. Finally, we draw upon a nearly 90-year history in biological Raman spectroscopy to provide the basis for laboratory and in-line measurements of protein quality, including higher-order structure and composition modifications, to support formulation development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.