ArticleAnalytical and bioanalytical chemistry2021
An ultrasensitive electrochemical aptasensor based on a single-stranded aptamer-Au@Fe-MIL-88 complex using methylene blue as an electrochemical probe for insulin detection.
Article in Analytical and bioanalytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 12 citations in OpenAlex.
- Recent trends on MIL-88(Fe) metal-organic frameworks: synthesis and applications in pollutant removal and detection.RSC advances · 2025Review
- A signal-off aptasensor for the determination of Acinetobacter baumannii by using methylene blue as an electrochemical probe.Mikrochimica acta · 2023Article
- Detection of Biomarker Using Aptasensors to Determine the Type of Diabetes.Diagnostics (Basel, Switzerland) · 2023Review
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This work introduces an electrochemical aptasensor based on a single-stranded aptamer-Au@Fe-MIL-88 complex for sensitive and selective determination of insulin using differential pulls voltammetry. Au@Fe-MIL-88 with a large surface area was synthesized and employed as a suitable substrate for immobilization of the aptamer (APT-Au@Fe-MIL-88). Methylene blue (MB), as an electrochemical probe, was intercalated into the aptamer. Graphene oxide (GO) and zinc sulfide (ZnS) were placed on the Au electrode to amplify the MB current. Also, ZnS improves the immobilization of APT-Au@Fe-MIL-88 into the aptasensor through the strong interaction of Au-S. In the presence of the insulin, MB is released from the aptamer due to DNA conformational change, and as a result, the peak intensity of the intercalated MB was decreased. Under optimal conditions, the change in the current of MB was proportional to the insulin concentration in the range of 5.0 × 10
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