Evidence map›Paper›PMID 34668994›Full record

ArticleEuropean radiology2022

Ultrashort echo time MRI of the lung in children and adolescents: comparison with non-enhanced computed tomography and standard post-contrast T1w MRI sequences.

Diane M Renz, Karl-Heinz Herrmann, Martin Kraemer, Joachim Boettcher, Matthias Waginger, Paul-Christian Krueger, Alexander Pfeil, Florian Streitparth, Karim Kentouche, Bernd Gruhn and 5 more

Abstract read
In one paragraph

Article in European radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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  12. Long COVID in Children: A Multidisciplinary Review.Diagnostics (Basel, Switzerland) · 2023
    Review
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  14. Article
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  18. Imaging Findings of Pediatric Rheumatic Disorders: JIA in the PRINTO Era and Autoimmune Interferonopathies.Pediatrics international : official journal of the Japan Pediatric Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Diane M RenzDepartment of Paediatric Radiology, Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. renz.diane@mh-hannover.de.
Karl-Heinz HerrmannMedical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.
Martin KraemerMedical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.
Joachim BoettcherFriedrich-Schiller-University, Jena, Germany.
Matthias WagingerDepartment of Paediatric Radiology, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.
Paul-Christian KruegerDepartment of Paediatric Radiology, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.
Alexander PfeilDepartment of Internal Medicine III, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.
Florian StreitparthDepartment of Radiology, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany.
Karim KentoucheDepartment of Paediatrics, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.
Bernd GruhnDepartment of Paediatrics, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.
Jochen G MainzDepartment of Paediatric Pulmonology and Cystic Fibrosis, Brandenburg Medical School, University Hospital, Brandenburg, Germany.
Martin StenzelDepartment of Paediatric Radiology, Children´s Hospital, Cologne, Germany.
Ulf K TeichgraeberInstitute of Diagnostic and Interventional Radiology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.
Juergen R ReichenbachMedical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.
Hans-Joachim MentzelDepartment of Paediatric Radiology, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo compare the diagnostic value of ultrashort echo time (UTE) magnetic resonance imaging (MRI) for the lung versus the gold standard computed tomography (CT) and two T1-weighted MRI sequences in children.

methodsTwenty-three patients with proven oncologic disease (14 male, 9 female; mean age 9.0 + / - 5.4 years) received 35 low-dose CT and MRI examinations of the lung. The MRI protocol (1.5-T) included the following post-contrast sequences: two-dimensional (2D) incoherent gradient echo (GRE; acquisition with breath-hold), 3D volume interpolated GRE (breath-hold), and 3D high-resolution radial UTE sequences (performed during free-breathing). Images were evaluated by considering image quality as well as distinct diagnosis of pulmonary nodules and parenchymal areal opacities with consideration of sizes and characterisations.

resultsThe UTE technique showed significantly higher overall image quality, better sharpness, and fewer artefacts than both other sequences. On CT, 110 pulmonary nodules with a mean diameter of 4.9 + / - 2.9 mm were detected. UTE imaging resulted in a significantly higher detection rate compared to both other sequences (p < 0.01): 76.4% (84 of 110 nodules) for UTE versus 60.9% (67 of 110) for incoherent GRE and 62.7% (69 of 110) for volume interpolated GRE sequences. The detection of parenchymal areal opacities by the UTE technique was also significantly higher with a rate of 93.3% (42 of 45 opacities) versus 77.8% (35 of 45) for 2D GRE and 80.0% (36 of 45) for 3D GRE sequences (p < 0.05).

conclusionThe UTE technique for lung MRI is favourable in children with generally high diagnostic performance compared to standard T1-weighted sequences as well as CT. Key Points • Due to the possible acquisition during free-breathing of the patients, the UTE MRI sequence for the lung is favourable in children. • The UTE technique reaches higher overall image quality, better sharpness, and lower artefacts, but not higher contrast compared to standard post-contrast T1-weighted sequences. • In comparison to the gold standard chest CT, the detection rate of small pulmonary nodules small nodules ≤ 4 mm and subtle parenchymal areal opacities is higher with the UTE imaging than standard T1-weighted sequences.

Indexed as

Imaging, Three-DimensionalMagnetic Resonance ImagingAdolescentBreath HoldingChildChild, PreschoolFemaleHumansLungMaleTomography, X-Ray ComputedChildLungMagnetic resonance imagingNeoplasmsTomography, x-ray computed

Identifiers

PMID34668994
PMCPMC8831263

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.