Evidence map›Paper›PMID 34668818›Full record

ArticleDrug delivery2021

Formulation, optimization, and nephrotoxicity evaluation of an antifungal in situ nasal gel loaded with voriconazole‒clove oil transferosomal nanoparticles.

Ahmed K Kammoun, Alaa Khedr, Maha A Hegazy, Ahmed J Almalki, Khaled M Hosny, Walaa A Abualsunun, Samar S A Murshid, Rana B Bakhaidar

Open access · goldAbstract read
In one paragraph

Article in Drug delivery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Ahmed K KammounDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Alaa KhedrDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Maha A HegazyAnalytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Ahmed J AlmalkiDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Khaled M HosnyDepartment of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.ORCID 0000-0002-4904-1378
Walaa A AbualsununDepartment of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Samar S A MurshidDepartment of Natural products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Rana B BakhaidarDepartment of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
King Abdulaziz University · SABeni-Suef University · EGCairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fungal infections of the paranasal cavity are among the most widely spread illnesses nowadays. The aim of the current study was to estimate the effectiveness of an in situ gel loaded with voriconazole‒clove oil nano-transferosomes (VRC-CO-NT) in enhancing the activity of voriconazole against

Indexed as

AnimalsAntifungal AgentsAspergillus flavusBacterial Outer Membrane ProteinsBiomarkersChemistry, PharmaceuticalClove OilCreatinineDose-Response Relationship, DrugDrug CarriersDrug LiberationGelsKidney DiseasesLiposomesNanoparticlesParanasal SinusesAntifungal AgentsBacterial Outer Membrane ProteinsBiomarkersClove OilCreatinineDrug CarriersGelsLiposomesSpaS protein, Salmonella typhimuriumVoriconazoleAntifungalbox‒behnken designclove oilrhinosinusitistransferosomesvoriconazole

Identifiers

PMID34668818
PMCPMC8530484
OpenAlexW3207971894

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.