Evidence map›Paper›PMID 34668811›Full record

ArticleDrug delivery2021

Ligand-modified homologous targeted cancer cell membrane biomimetic nanostructured lipid carriers for glioma therapy.

Mengyu Chen, Yuexin Cui, Wenyan Hao, Yueyue Fan, Jingqiu Zhang, Qianqian Liu, Mingrui Jiang, Yang Yang, Yingzi Wang, Chunsheng Gao

Open access · goldAbstract read
In one paragraph

Article in Drug delivery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Nanotherapy of Glioblastoma-Where Hope Grows.International journal of molecular sciences · 2025
    Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Mengyu ChenSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People's Republic of China.
Yuexin CuiSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People's Republic of China.
Wenyan HaoState Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, People's Republic of China.
Yueyue FanState Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, People's Republic of China.
Jingqiu ZhangSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People's Republic of China.
Qianqian LiuSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People's Republic of China.
Mingrui JiangSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People's Republic of China.
Yang YangState Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, People's Republic of China.
Yingzi WangSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People's Republic of China.
Chunsheng GaoState Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, People's Republic of China.
Beijing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The main treatment measure currently used for glioma treatment is chemotherapy; the biological barrier of solid tumors hinders the deep penetration of nanomedicines and limits anticancer therapy. Furthermore, the poor solubility of many chemotherapeutic drugs limits the efficacy of antitumor drugs. Therefore, improving the solubility of chemotherapeutic agents and drug delivery to tumor tissues through the blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB) are major challenges in glioma treatment. Nanostructured lipid carriers (NLCs) have high drug loading capacity, high stability, and high

Indexed as

AnimalsAntineoplastic AgentsArtemisininsBiomimeticsBlood-Brain BarrierBrain NeoplasmsCell Line, TumorChemistry, PharmaceuticalDrug Delivery SystemsGliomaLigandsMembrane LipidsMiceNanoparticlesOligopeptidesAntineoplastic AgentsArtemisininsartenimolasparagine-glycine-arginineLigandsMembrane LipidsOligopeptidesbiomimetic drug-delivery systemblood–brain barriercancer cell membranesgliomasNanostructured lipid carriers

Identifiers

PMID34668811
PMCPMC8530486
OpenAlexW3207338011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.