Evidence map›Paper›PMID 34668789›Full record

ArticleThe American journal of sports medicine2021

Regional Differences in Anterior Cruciate Ligament Signal Intensity After Surgical Treatment.

Ata M Kiapour, Sean W Flannery, Martha M Murray, Patricia E Miller, BEAR Trial Team, Benedikt L Proffen, Nicholas Sant, Gabriela Portilla, Ryan Sanborn, Christina Freiberger and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of sports medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 14 citations in OpenAlex.

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  12. Automated segmentation of the healed anterior cruciate ligament from TJournal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Ata M KiapourDepartment of Orthopaedic Surgery and Sports Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Sean W FlanneryDepartment of Orthopaedics, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, Rhode Island, USA.
Martha M MurrayInvestigation performed at Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Patricia E MillerDepartment of Orthopaedic Surgery and Sports Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
BEAR Trial TeamInvestigation performed at Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Benedikt L ProffenInvestigation performed at Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Nicholas SantInvestigation performed at Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Gabriela PortillaInvestigation performed at Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Ryan SanbornInvestigation performed at Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Christina FreibergerInvestigation performed at Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Rachael HendersonInvestigation performed at Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Samuel BarnettInvestigation performed at Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Kirsten EcklundInvestigation performed at Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Yi-Meng YenInvestigation performed at Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Dennis E KramerInvestigation performed at Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Lyle J MicheliBoston Children's Hospital Boston, Massachusetts, USA.
Braden C FlemingDepartment of Orthopaedics, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, Rhode Island, USA.ORCID 0000-0002-7841-425X
Boston Children's Hospital · US

Funding

Biologically Enhanced Healing of Autograft ACL Reconstruction.R01AR056834 · NIAMS · RHODE ISLAND HOSPITAL · PI FLEMING, BRADEN C, MURRAY, MARTHA M · 2009 to 2017
$5.8M
Non-invasive Assessment of Ligament Healing, in VivoR01AR065462 · NIAMS · RHODE ISLAND HOSPITAL · PI FLEMING, BRADEN C, MURRAY, MARTHA M · 2014 to 2016
$2.1M
NIAMS NIH HHS R01 AR056834NIAMS NIH HHS R01 AR065462
6 · The paper itself

Abstract

backgroundMagnetic resonance-based measurements of signal intensity have been used to track healing of surgically treated anterior cruciate ligaments (ACLs). However, it is unknown how the signal intensity values in different regions of the ligament or graft change during healing. HYPOTHESES: (1) Normalized signal intensity of the healing graft or repaired ACL is heterogeneous; (2) temporal changes in normalized signal intensity values differ among the tibial, middle, and femoral regions; and (3) there are no differences in regional normalized signal intensity values 2 years postoperatively among grafts, repaired ACLs, and contralateral native ACLs. STUDY

designCohort study; Level of evidence, 2.

methodsMagnetic resonance imaging scans were analyzed from patients in a trial comparing ACL reconstruction (n = 35) with bridge-enhanced ACL repair (n = 65). The ACLs were segmented from images acquired at 6, 12, and 24 months postoperatively and were partitioned into 3 sections along the longitudinal axis (femoral, middle, and tibial). Linear mixed modeling was used to compare location-specific differences in normalized ligament signal intensity among time points (6, 12, and 24 months) and groups (ACL reconstruction, repair, and contralateral native ACL).

resultsFor grafts, the middle region had a higher mean normalized signal intensity when compared with the femoral region at all time points (

conclusionThe results suggest that graft remodeling is location specific. Repaired ACLs were more homogeneous, with lower or comparable normalized signal intensity values at 2 years as compared with the contralateral native ACL and reconstructed grafts.

Indexed as

Anterior Cruciate Ligament InjuriesAnterior Cruciate Ligament ReconstructionAnterior Cruciate LigamentCohort StudiesHumansMagnetic Resonance ImagingTibiaACL MRI signal intensityACL reconstructionACL repairhealingremodeling

Identifiers

PMID34668789
PMCPMC8829819
OpenAlexW3207264516

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.