Evidence map›Paper›PMID 34668779›Full record

ArticleJournal of virology2022

Viral and Cellular Factors Leading to the Loss of CD4 Homeostasis in HIV-1 Viremic Nonprogressors.

Marta Colomer-Lluch, Athina Kilpelainen, María Pernas, Ruth Peña, Dan Ouchi, Esther Jimenez-Moyano, Judith Dalmau, Concepción Casado, Cecilio López-Galíndez, Bonaventura Clotet and 2 more

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Marta Colomer-LluchIrsiCaixa AIDS Research Institute, Badalona, Spain.
Athina KilpelainenIrsiCaixa AIDS Research Institute, Badalona, Spain.
María PernasUnidad de Virología Molecular, Laboratorio de Referencia e Investigación en Retrovirus, Centro Nacional de Microbiología, Instituto de Salud Carlos IIIgrid.413448.e, Majadahonda, Madrid, Spain.
Ruth PeñaIrsiCaixa AIDS Research Institute, Badalona, Spain.
Dan OuchiIrsiCaixa AIDS Research Institute, Badalona, Spain.
Esther Jimenez-MoyanoIrsiCaixa AIDS Research Institute, Badalona, Spain.
Judith DalmauIrsiCaixa AIDS Research Institute, Badalona, Spain.
Concepción CasadoUnidad de Virología Molecular, Laboratorio de Referencia e Investigación en Retrovirus, Centro Nacional de Microbiología, Instituto de Salud Carlos IIIgrid.413448.e, Majadahonda, Madrid, Spain.
Cecilio López-GalíndezUnidad de Virología Molecular, Laboratorio de Referencia e Investigación en Retrovirus, Centro Nacional de Microbiología, Instituto de Salud Carlos IIIgrid.413448.e, Majadahonda, Madrid, Spain.
Bonaventura ClotetIrsiCaixa AIDS Research Institute, Badalona, Spain.
Javier Martinez-PicadoIrsiCaixa AIDS Research Institute, Badalona, Spain.ORCID 0000-0002-4916-2129
Julia G PradoIrsiCaixa AIDS Research Institute, Badalona, Spain.ORCID 0000-0002-5439-4645
IrsiCaixa · ESInstitut d'Investigació en Ciències de la Salut Germans Trias i Pujol · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human immunodeficiency virus type 1 (HIV-1) viremic nonprogressors (VNPs) represent a very rare HIV-1 extreme phenotype. VNPs are characterized by persistent high plasma viremia and maintenance of CD4

Indexed as

CD4 Lymphocyte CountHost-Pathogen InteractionsViral LoadFemalegag Gene Products, Human Immunodeficiency VirusHIV-1HIV InfectionsHumansLymphocyte ActivationMalePhylogenyReceptors, CCR5Receptors, CCR6Receptors, CXCR4Signal TransductionT-Lymphocyte SubsetsCCR6 protein, humanCXCR4 protein, humangag Gene Products, Human Immunodeficiency VirusReceptors, CCR5Receptors, CCR6Receptors, CXCR4CCR5coreceptor usageCXCR6HIV-1human immunodeficiency virusloss of CD4 homeostasisreplicationT-cell activationT-cell maturational phenotypesviremic nonprogressors

Identifiers

PMID34668779
PMCPMC8754213
OpenAlexW3206603629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.