Observational studyMicrobiology spectrum2021
COVID-19-Associated Pulmonary Aspergillosis, Fungemia, and Pneumocystosis in the Intensive Care Unit: a Retrospective Multicenter Observational Cohort during the First French Pandemic Wave.
Open access · goldAbstract readMulticenter StudyObservational Study
In one paragraph
Observational study in Microbiology spectrum, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
2.7field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Incidence, mortality and risk factors of invasive pulmonary aspergillosis in critically ill patients during the COVID-19 era: a global systematic review and meta-analysis.Annals of clinical microbiology and antimicrobials · 2026Pooled it
- Global prevalence, mortality, and main characteristics of HIV-associated pneumocystosis: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Clinical presentations, diagnosis, management, and outcomes of renal mucormycosis: An overview of case reports.Frontiers in medicine · 2022Pooled it
- Fungi identified via next-generation sequencing in bronchoalveolar lavage fluid among patients with COVID-19: a retrospective study.European journal of medical research · 2024Article
- Impact of the COVID-19 Pandemic on Inpatient Antibiotic and Antifungal Drug Prescribing Volumes in Germany.Antibiotics (Basel, Switzerland) · 2024Article
- Investigation of risk factors for invasive pulmonary aspergillosis among patients with COVID-19.Scientific reports · 2024Article
- Severe mold fungal infections in critically ill patients with COVID-19.Future microbiology · 2024Review
- An enhanced IL17 and muted type I interferon nasal epithelial cell state characterizes severe COVID-19 with fungal coinfection.Microbiology spectrum · 2024Article
- Mixed Aspergillosis and Mucormycosis Infections in Patients with COVID-19: Case Series and Literature Review.Mycopathologia · 2024Review
- Potential Drugs in COVID-19 Management.Current medicinal chemistry · 2024Review
- A Tale of Two Hospitals: Comparing CAPA Infections in Two ICUs During the Spanish Fourth Pandemic Wave.Mycopathologia · 2023Article
- Trends in the Epidemiology ofJournal of fungi (Basel, Switzerland) · 2023Review
- Mortality in ICU Patients with COVID-19-Associated Pulmonary Aspergillosis.Journal of fungi (Basel, Switzerland) · 2023Review
- COVID-19 associated mold infections: Review of COVID-19 associated pulmonary aspergillosis and mucormycosis.Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi · 2023Review
- Risk of Coronavirus Disease 2019-Associated Pulmonary Aspergillosis Based on Corticosteroid Duration in Intensive Care Patients.Open forum infectious diseases · 2023Article
- Article
- Invasive Fungal Infections in Hospitalized Patients with COVID-19: A Non-Intensive Care Single-Centre Experience during the First Pandemic Waves.Journal of fungi (Basel, Switzerland) · 2023Article
- Post-COVID-19Access microbiology · 2023Article
- Invasive Fungal Diseases in Hospitalized Patients with COVID-19 in Israel: A Multicenter Cohort Study.Journal of fungi (Basel, Switzerland) · 2022Article
- Rapid Detection of Bacterial and Fungal Pathogens Using the T2MR versus Blood Culture in Patients with Severe COVID-19.Microbiology spectrum · 2022Article
Corrections and comments
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Authors and funding
36 authors at 20 institutions in 2 countries.
Stéphane BretagneInstitut Pasteur, Université de Paris, CNRS UMR2000, unité de Mycologie Moléculaire, Centre national de Référence Mycoses Invasives et Antifongiques, Paris, France.ORCID 0000-0001-6870-3800
Karine SitbonInstitut Pasteur, Université de Paris, CNRS UMR2000, unité de Mycologie Moléculaire, Centre national de Référence Mycoses Invasives et Antifongiques, Paris, France.
Françoise BotterelAssistance Publique-Hôpitaux De Paris (AP-HP), Hôpital Henri Mondor, Université Paris-Est Créteil Val-de-Marne, Créteil, France.
Sarah DellièreInstitut Pasteur, Université de Paris, CNRS UMR2000, unité de Mycologie Moléculaire, Centre national de Référence Mycoses Invasives et Antifongiques, Paris, France.ORCID 0000-0003-3821-1762
Valérie Letscher-BruService de Parasitologie et de Mycologie Médicale, CHU de Strasbourg, Strasbourg, France.
Taieb ChouakiLaboratoire de Parasitologie-Mycologie, CHU Amiens-Picardie, Amiens, France.
Anne-Pauline BellangerLaboratoire de Parasitologie-Mycologie, CHU Besançon, Besançon, France.
Christine BonnalAssistance Publique-Hôpitaux De Paris (AP-HP), Laboratoire de Parasitologie-Mycologie, Hôpital Universitaire Bichat, Paris, France.
Arnault FekkarAssistance Publique-Hôpitaux De Paris (AP-HP), Groupe Hospitalier La Pitié-Salpêtrière, Service de Parasitologie Mycologie, Sorbonne Université, Inserm, CNRS, Centre d'Immunologie et des Maladies Infectieuses (CIMI), Paris, France.ORCID 0000-0001-9954-075X
Florence PersatHospices Civils de Lyongrid.413852.9, Service de Parasitologie et Mycologie Médicale, Hôpital de la Croix-Rousse, Lyon-Université Claude Bernard Lyon 1, Lyon, France.
Damien CostaLaboratoire de Parasitologie-Mycologie, CHU Charles-Nicolle, Rouen, France.
Nathalie BourgeoisLaboratoire de Parasitologie-Mycologie, CHU de Montpellier, Montpellier, France.
Frédéric DalleLaboratoire de Parasitologie Mycologie, Centre Hospitalier Universitaire de Dijon-Hôpital François Mitterrand, Dijon, France.
Florian Lussac-SortonDepartment of Parasitology, Bordeaux University Hospital, Bordeaux, France.
André PaugamUniversité de Paris, Paris, France.
Sophie CassaingService de Parasitologie-Mycologie, Hôpital Purpan Toulouse, CHU Toulouse, Toulouse, France.
Lilia HasseineLaboratoire de Parasitologie Mycologie CHU de Nice, Nice, France.
Antoine HugueninParasitologie Mycologie-Laboratoire de Parasitologie-Mycologie, Pôle de Biopathologie, CHU de Reims, Université de Reims Champagne Ardenne, Reims, France.
Nadia GuennouniAssistance Publique-Hôpitaux De Paris (AP-HP), Service de Bactériologie, Virologie, Parasitologie et Hygiène, Hôpital Necker-Enfants Malades, IHU Imagine, Paris, France.
Edith MazarsCH de Valenciennes, Laboratoire de Microbiologie, Valenciennes, France.
Solène Le GalLaboratoire de Parasitologie et Mycologie, Hôpital de La Cavale Blanche, CHU de Brest, Brest, France.
Milène SassoLaboratoire de Parasitologie Mycologie CHU Nîmes, Nîmes, France.ORCID 0000-0002-6539-8545
Sophie BrunAssistance Publique-Hôpitaux De Paris (AP-HP), Laboratoire de Parasitologie Mycologie Hôpital Avicenne, Bobigny, France.
Lucile CadotDépartement d'Hygiène Hospitalière, CHU Montpellier, Montpellier, France.
Carole CassagneIHU Marseille-Institut Hospitalier Universitaire Méditerranée Infection, Marseille, France.
Estelle CateauLaboratoire de Parasitologie-Mycologie, CHU de Poitiers, Poitiers, France.
Jean-Pierre GangneuxCHU de Rennes, Université de Rennes, Institut de Recherche en Santé, Environnement et Travail (IRSET), Rennes, France.
Maxime MoniotLaboratoire de Parasitologie-Mycologie, CHU Clermont-Ferrand, Clermont-Ferrand, France.
Anne-Laure RouxAssistance Publique-Hôpitaux De Paris (AP-HP), Hôpital Raymond Poincaré Garches, Hôpital Ambroise Paré, Boulogne Billancourt, France.
Céline TournusLaboratoire de Microbiologie, Centre Hospitalier de Saint-Denis, Saint-Denis, France.
Nicole Desbois-NogardLaboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Martiniquegrid.412874.c, Fort-de-France, La Martinique, France.
Alain Le CoustumierCentre Hospitalier Intercommunal de Bigorre, Tarbes, France.
Olivier MoquetLaboratoire de Parasitologie-Mycologie, Centre Hospitalier de Beauvais, Beauvais, France.
Alexandre AlanioInstitut Pasteur, Université de Paris, CNRS UMR2000, unité de Mycologie Moléculaire, Centre national de Référence Mycoses Invasives et Antifongiques, Paris, France.ORCID 0000-0001-9726-3082
Françoise DromerInstitut Pasteur, Université de Paris, CNRS UMR2000, unité de Mycologie Moléculaire, Centre national de Référence Mycoses Invasives et Antifongiques, Paris, France.ORCID 0000-0003-1671-1475
French Mycoses Study Group
Centre National de la Recherche Scientifique · FRAssistance Publique – Hôpitaux de Paris · FRCentre Hospitalier Universitaire de Montpellier · FRCentre Hospitalier de Beauvais · FRCentre Hospitalier de Bigorre · FRCentre Hospitalier de Valenciennes · FRCentre Hospitalier Saint-Denis · FRCentre Hospitalier Universitaire Amiens-Picardie · FRCentre Hospitalier Universitaire de Besançon · FRCentre Hospitalier Universitaire de Clermont-Ferrand · FRCentre Hospitalier Universitaire de Martinique · MQCentre Hospitalier Universitaire de Nice · FRCentre Hospitalier Universitaire de Nîmes · FRCentre Hospitalier Universitaire de Poitiers · FRCentre Hospitalier Universitaire de Reims · FRCHU Dijon Bourgogne · FRHôpital Charles-Nicolle · FRHôpital Civil, Strasbourg · FRHôpital Maison Blanche · FRHôpital Necker-Enfants Malades · FR
Funding
Agence Nationale de la Recherche (ANR) 20CE35000701
Abstract
The aim of this study was to evaluate diagnostic means, host factors, delay of occurrence, and outcome of patients with COVID-19 pneumonia and fungal coinfections in the intensive care unit (ICU). From 1 February to 31 May 2020, we anonymously recorded COVID-19-associated pulmonary aspergillosis (CAPA), fungemia (CA-fungemia), and pneumocystosis (CA-PCP) from 36 centers, including results on fungal biomarkers in respiratory specimens and serum. We collected data from 154 episodes of CAPA, 81 of CA-fungemia, 17 of CA-PCP, and 5 of other mold infections from 244 patients (male/female [M/F] ratio = 3.5; mean age, 64.7 ± 10.8 years). CA-PCP occurred first after ICU admission (median, 1 day; interquartile range [IQR], 0 to 3 days), followed by CAPA (9 days; IQR, 5 to 13 days), and then CA-fungemia (16 days; IQR, 12 to 23 days) (
Indexed as
AgedAntifungal AgentsCoinfectionCOVID-19Critical CareFemaleFranceFungemiaGalactoseHumansIntensive Care UnitsMaleMannansMiddle AgedPneumonia, PneumocystisPulmonary AspergillosisAntifungal AgentsgalactomannanGalactoseMannansaspergillosisAspergillusCOVID-19critical careFrancefungemiapneumocystosis
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