Evidence map›Paper›PMID 34668760›Full record

ArticleMolecular biology of the cell2021

Protein phosphatase 2A (PP2A) promotes anaphase entry after DNA replication stress in budding yeast.

Cory Haluska, Fengzhi Jin, Yanchang Wang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Cory HaluskaDepartment of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306-4300.
Fengzhi JinDepartment of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306-4300.
Yanchang WangDepartment of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306-4300.
Florida State University · US

Funding

The Initiation of DNA Replication in EukaryotesR01GM121786 · NIGMS · FLORIDA STATE UNIVERSITY · PI WANG, YANCHANG · 2017 to 2020
$1.2M
NIGMS NIH HHS R01 GM121786
6 · The paper itself

Abstract

DNA replication stress activates the S-phase checkpoint that arrests the cell cycle, but it is poorly understood how cells recover from this arrest. Cyclin-dependent kinase (CDK) and protein phosphatase 2A (PP2A) are key cell cycle regulators, and Cdc55 is a regulatory subunit of PP2A in budding yeast. We found that yeast cells lacking functional PP2A

Indexed as

AnaphaseCDC2 Protein KinaseCell Cycle ProteinsCheckpoint Kinase 1DNA ReplicationGreen Fluorescent ProteinsHydroxyureaMicroorganisms, Genetically-ModifiedMutationPhosphorylationProtein Phosphatase 2Protein-Tyrosine KinasesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSecurinS PhaseCDC2 Protein KinaseCDC55 protein, S cerevisiaeCell Cycle ProteinsCheckpoint Kinase 1Green Fluorescent ProteinsHydroxyureaPDS1 protein, S cerevisiaePPH21 protein, S cerevisiaePph22 protein, S cerevisiaeProtein Phosphatase 2Protein-Tyrosine KinasesSaccharomyces cerevisiae ProteinsSecurinSWE1 protein, S cerevisiae

Identifiers

PMID34668760
PMCPMC8694091
OpenAlexW3207413629

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.