Evidence map›Paper›PMID 34668739›Full record

ArticleMicrobiology spectrum2021

Network-Based Approaches Reveal Potential Therapeutic Targets for Host-Directed Antileishmanial Therapy Driving Drug Repurposing.

J Eduardo Martinez-Hernandez, Zaynab Hammoud, Alessandra Mara de Sousa, Frank Kramer, Rubens L do Monte-Neto, Vinicius Maracaja-Coutinho, Alberto J M Martin

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Transcription-based comparison ofMicrobiology spectrum · 2026
    Article
  2. Retinoic acid-loaded nanoparticles enhance macrophage-mediated control ofTurkish journal of biology = Turk biyoloji dergisi · 2026
    Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

J Eduardo Martinez-HernandezPrograma de Doctorado en Genómica Integrativa, Vicerrectoría de Investigación, Universidad Mayorgrid.412199.6, Santiago, Chile.ORCID 0000-0003-0739-0999
Zaynab HammoudIT-Infrastructure for Translational Medical Research, University of Augsburg, Augsburg, Germany.ORCID 0000-0001-5943-3941
Alessandra Mara de SousaBiotecnologia Aplicada ao Estudo de Patógenos - Instituto René Rachou - Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil.
Frank KramerIT-Infrastructure for Translational Medical Research, University of Augsburg, Augsburg, Germany.ORCID 0000-0002-2857-7122
Rubens L do Monte-NetoBiotecnologia Aplicada ao Estudo de Patógenos - Instituto René Rachou - Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil.ORCID 0000-0002-4688-2462
Vinicius Maracaja-CoutinhoAdvanced Center for Chronic Diseases - ACCDiS, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile.ORCID 0000-0002-8873-9381
Alberto J M MartinLaboratorio de Biología de Redes, Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayorgrid.412199.6, Santiago, Chile.ORCID 0000-0002-6147-3325
Fundação Oswaldo Cruz · BRUniversidad Mayor · CLUniversity of Augsburg · DEAdvanced Center for Chronic Diseases · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antiprotozoal AgentsDrug RepositioningGene Expression ProfilingHumansLeishmania majorLeishmaniasisMacrophagesMetabolic Networks and PathwaysTranscriptomeAntiprotozoal Agentsdrug repurposinggene regulatory networkshost-direct therapyleishmaniasismultilayered network

Identifiers

PMID34668739
PMCPMC8528132
OpenAlexW3205911621

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.