ArticleMolecular genetics & genomic medicine2021
Predictors of empowerment in parents of children with autism and related neurodevelopmental disorders who are undergoing genetic testing.
Article in Molecular genetics & genomic medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- The personal utility of genetic testing in children with epilepsy.Journal of genetic counseling · 2026Article
- Examining parents' perceptions of their children's autism and completion of genetic testing.International journal of developmental disabilities · 2025Article
- Predictors of empowerment in parents of children with autism and related neurodevelopmental disorders who are undergoing genetic testing.Molecular genetics & genomic medicine · 2021Article
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Authors and funding
8 authors at 5 institutions in 1 country.
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Abstract
backgroundThere is limited empirical data quantifying the utility of genetic testing for families of children with autism spectrum disorder (ASD) or related neurodevelopmental disorders (NDD). We assessed the utility of clinical chromosomal microarray analysis (CMA), defined by diagnostic yield and parental empowerment, in population-based sample of parents of affected children; and explored child, family, and health services factors predictive of empowerment.
methodsParticipants were families of children undergoing diagnostic assessments, between 2016 and 2019. Diagnostic yield of CMA in affected children was determined. Parental empowerment was measured through adapted version of the Genetics Counseling Outcome Scale-24. Parents completed questionnaires to capture child, family, and health service factors.
resultsThe diagnostic yield of CMA was 2.8% for pathogenic variants. Parental empowerment was significantly correlated with family functioning and aspects of perceived family-centeredness of care. The model accounted for 49.8% of the variation in parental empowerment, F (10,37) = 3.67, p = 0.002. After accounting for other predictors, parental perception of the provision of general information remained significantly associated with empowerment.
conclusionThe informational needs of families play an important role in their empowerment during genetic testing. Meeting these needs and monitoring empowerment can aid genomic technologies integration in personalized healthcare for ASD/NDD.
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