Evidence map›Paper›PMID 34668649›Full record

SynthesisThoracic cancer2021

Diagnostic performance of dynamic contrast-enhanced magnetic resonance imaging for breast cancer detection: An update meta-analysis.

Honghuan Dong, Linqing Kang, Sijia Cheng, Rongju Zhang

Open access · goldAbstract readMeta-Analysis
In one paragraph

Synthesis in Thoracic cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
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  6. Review
  7. Article
  8. Improvement in breast lesion classification utilizing deep learning and treatment response assessment maps (TRAMs).Proceedings of SPIE--the International Society for Optical Engineering · 2025
    Article
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  11. Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Honghuan DongDepartment of MRI, Cang Zhou Central Hospital, Cangzhou, China.ORCID 0000-0003-4680-121X
Linqing KangDepartment of MRI, Cang Zhou Central Hospital, Cangzhou, China.
Sijia ChengDepartment of MRI, Cang Zhou Central Hospital, Cangzhou, China.
Rongju ZhangDepartment of Pathology, Cang Zhou Central Hospital, Cangzhou, China.
Cangzhou Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the diagnostic performance of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for breast cancer identification.

methodsA comprehensive electronic systematic searching of Medline, Ovid, EMBASE, Web of Science, CNK, and Cochrane Library databases was performed up to 2 August 2021. Clinical studies associated with DCE-MRI for breast cancer detection were screened and inlcuded in the meta-analysis. The data of true positive(tp), false positive(fp), false negative(fn) and true negative(tn) was extracted from includded studies. The sensitivity, specificity, diagnostic odds ratio (DOR), and area under the summary receiver operating characteristic (SROC) were pooled under fixed or random effect models. Publication bias was evaluated by Deek's funnel plot.

resultsA final set of 15 studies with 1321 breast lesions were included in the present work. The pooled diagnostic sensitivity, specificity, and DOR were 0.87 (95% confidence interval [CI] 0.81-0.92), 0.74 (95% CI 0.68-0.80), and 18.83 (95% CI 9.07-36.54), respectively, and the area under the SROC was 0.86 (95% CI 0.82-0.88). Given a pretest probability of 50%, the positive post-test probability was 77%, and the negative post-test probability was 14%. Deek's funnel plot indicated low publication bias (p = 0.61).

conclusionDCE-MRI is a noninvasive method of breast cancer diagnosis for suspected malignant breast lesions with relative high diagnostic sensitivity and specificity.

Indexed as

Breast NeoplasmsContrast MediaHumansImage EnhancementMagnetic Resonance ImagingROC CurveSensitivity and SpecificityContrast Mediabreast cancerDCE-MRIdiagnosismeta-analysis

Identifiers

PMID34668649
PMCPMC8636198
OpenAlexW3207229053

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.