Evidence map›Paper›PMID 34668564›Full record

ArticleSystematic biology2022

Relative Time Constraints Improve Molecular Dating.

Gergely J Szöllõsi, Sebastian Höhna, Tom A Williams, Dominik Schrempf, Vincent Daubin, Bastien Boussau

Abstract read
In one paragraph

Article in Systematic biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. DPANN Archaea and CPR Bacteria: insights into early cellular evolution?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  4. Article
  5. Challenges in Assembling the Dated Tree of Life.Genome biology and evolution · 2024
    Article
  6. Article
  7. Article
  8. Relative timing information and orthology in evolutionary scenarios.Algorithms for molecular biology : AMB · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Snowball Earth, population bottleneck andProceedings. Biological sciences · 2021
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gergely J SzöllõsiMTA-ELTE "Lendület"' Evolutionary Genomics Research Group, Pázmány P. stny. 1A, H-1117 Budapest, Hungary.
Sebastian HöhnaGeoBio-Center LMU, Ludwig-Maximilians-Universität München, Richard-Wagner Straße 10, 80333 Munich, Germany.
Tom A WilliamsSchool of Biological Sciences, University of Bristol, 24 Tyndall Avenue, Bristol BS8 1TH, UK.
Dominik SchrempfDepartment of Biological Physics, Eötvös University, Pázmány P. stny. 1A., H-1117 Budapest, Hungary.
Vincent DaubinUniversité de Lyon, Université Lyon 1, CNRS, Laboratoire de Biométrie et Biologie Evolutive UMR 5558, F-69622 Villeurbanne, France.
Bastien BoussauUniversité de Lyon, Université Lyon 1, CNRS, Laboratoire de Biométrie et Biologie Evolutive UMR 5558, F-69622 Villeurbanne, France.

Funding

European Research Council
6 · The paper itself

Abstract

Dating the tree of life is central to understanding the evolution of life on Earth. Molecular clocks calibrated with fossils represent the state of the art for inferring the ages of major groups. Yet, other information on the timing of species diversification can be used to date the tree of life. For example, horizontal gene transfer events and ancient coevolutionary interactions such as (endo)symbioses occur between contemporaneous species and thus can imply temporal relationships between two nodes in a phylogeny. Temporal constraints from these alternative sources can be particularly helpful when the geological record is sparse, for example, for microorganisms, which represent the majority of extant and extinct biodiversity. Here, we present a new method to combine fossil calibrations and relative age constraints to estimate chronograms. We provide an implementation of relative age constraints in RevBayes that can be combined in a modular manner with the wide range of molecular dating methods available in the software. We use both realistic simulations and empirical datasets of 40 Cyanobacteria and 62 Archaea to evaluate our method. We show that the combination of relative age constraints with fossil calibrations significantly improves the estimation of node ages. [Archaea, Bayesian analysis, cyanobacteria, dating, endosymbiosis, lateral gene transfer, MCMC, molecular clock, phylogenetic dating, relaxed molecular clock, revbayes, tree of life.].

Indexed as

FossilsGene Transfer, HorizontalBayes TheoremEvolution, MolecularPhylogenySymbiosis

Identifiers

PMID34668564
PMCPMC9203062

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.