ArticlePlant physiology2022
Flavonoid deficiency disrupts redox homeostasis and terpenoid biosynthesis in glandular trichomes of tomato.
Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Integration of Spatiotemporal Multi-Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome-Mediated Stress Adaptation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Evolutionary origin of neohesperidoside, a bitter metabolite, and its potential role in biotic defense and citrus dissemination.Plant communications · 2026Article
- Insights into glandular trichome biology from analysis of organ-specific gene expression programmes in cannabis, hop and tomato.The Plant journal : for cell and molecular biology · 2026Article
- Hydrogen sulfide alleviates thiocyanate stress in rice seedlings via tissue-specific carbon and nitrogen metabolic reprogramming.Frontiers in plant science · 2026Article
- Antioxidant properties of dihydroxy B-ring flavonoids modulate circadian amplitude inLife science alliance · 2025Article
- A Comprehensive Review of Phenolic Compounds in Horticultural Plants.International journal of molecular sciences · 2025Review
- Omics-based identification of the broader effects of 2-hydroxyisoflavanone synthase gene editing on a gene regulatory network beyond isoflavonoid loss in soybean hairy roots.Plant & cell physiology · 2025Article
- Multiscale Mathematical Modeling in Systems Biology: A Framework to Boost Plant Synthetic Biology.Plants (Basel, Switzerland) · 2025Review
- Antioxidants by nature: an ancient feature at the heart of flavonoids' multifunctionality.The New phytologist · 2025Article
- Transcriptome and Metabolome Analyses Reveal a Complex Stigma Microenvironment for Pollen Tube Growth in Tobacco.International journal of molecular sciences · 2024Article
- Delineating Molecular Regulatory of Flavonoids Indicated by Transcriptomic and Metabolomics Analysis during Flower Development inInternational journal of molecular sciences · 2024Article
- Phytohormones in a universe of regulatory metabolites: lessons from jasmonate.Plant physiology · 2024Review
- Physiological and biochemical mechanisms underlying the role of anthocyanin in acquired tolerance to salt stress in peanut (Frontiers in plant science · 2024Article
- Effect ofPeerJ · 2024Article
- Tomato defences modulate not only insect performance but also their gut microbial composition.Scientific reports · 2023Article
- Homeostasis of flavonoids and triterpenoids most likely modulates starch metabolism for pollen tube penetration in rice.Plant biotechnology journal · 2023Article
- Trichome-Specific Analysis and Weighted Gene Co-Expression Correlation Network Analysis (WGCNA) Reveal Potential Regulation Mechanism of Artemisinin Biosynthesis inInternational journal of molecular sciences · 2023Article
- Flavonols modulate plant development, signaling, and stress responses.Current opinion in plant biology · 2023Review
- Multifaceted roles of WRKY transcription factors in abiotic stress and flavonoid biosynthesis.Frontiers in plant science · 2023Review
- Natural variation in the transcription factor REPLUMLESS contributes to both disease resistance and plant growth in Arabidopsis.Plant communications · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Glandular trichomes (GTs) are epidermal structures that provide the first line of chemical defense against arthropod herbivores and other biotic threats. The most conspicuous structure on leaves of cultivated tomato (Solanum lycopersicum) is the type-VI GT (tVI-GT), which accumulates both flavonoids and volatile terpenoids. Although these classes of specialized metabolites are derived from distinct metabolic pathways, previous studies with a chalcone isomerase 1 (CHI1)-deficient mutant called anthocyanin free (af) showed that flavonoids are required for terpenoid accumulation in tVI-GTs. Here, we combined global transcriptomic and proteomic analyses of isolated trichomes as a starting point to show that the lack of CHI1 is associated with reduced levels of terpenoid biosynthetic transcripts and enzymes. The flavonoid deficiency in af trichomes also resulted in the upregulation of abiotic stress-responsive genes associated with DNA damage and repair. Several lines of biochemical and genetic evidence indicate that the terpenoid defect in af mutants is specific for the tVI-GT and is associated with the absence of bulk flavonoids rather than loss of CHI1 per se. A newly developed genome-scale model of metabolism in tomato tVI-GTs helped identify metabolic imbalances caused by the loss of flavonoid production. We provide evidence that flavonoid deficiency in this cell type leads to increased production of reactive oxygen species (ROS), which may impair terpenoid biosynthesis. Collectively, our findings support a role for flavonoids as ROS-scavenging antioxidants in GTs.
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