Evidence map›Paper›PMID 34668438›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2021

Sex differences in the effect of acute intermittent hypoxia on respiratory modulation of sympathetic activity.

Jane S Edmunds, Clayton L Ivie, Elizabeth P Ott, Dain W Jacob, Sarah E Baker, Jennifer L Harper, Camila M Manrique-Acevedo, Jacqueline K Limberg

Abstract readComparative Study
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jane S EdmundsDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri.
Clayton L IvieDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri.
Elizabeth P OttDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri.
Dain W JacobDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri.
Sarah E BakerDepartment of Anesthesiology, Mayo Clinic, Rochester, Minnesota.
Jennifer L HarperDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri.
Camila M Manrique-AcevedoDepartment of Medicine, University of Missouri, Columbia, Missouri.ORCID 0000-0001-9341-404X
Jacqueline K LimbergDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri.ORCID 0000-0001-9982-5851

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's DiseaseU54AG044170 · NIA · MAYO CLINIC ROCHESTER · PI KAPOOR, EKTA · 2018 to 2022
$7.7M
Sex disparities in hypoxic sympatholysis and impact of obesityR01HL153523 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI LIMBERG, JACQUELINE K · 2020 to 2024
$2.7M
Reflex responses to intermittent hypoxia in humans: Mechanisms and consequencesR00HL130339 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI LIMBERG, JACQUELINE K · 2017 to 2019
$729k
Reflex responses to intermittent hypoxia in humans: Mechanisms and consequencesK99HL130339 · NHLBI · MAYO CLINIC ROCHESTER · PI LIMBERG, JACQUELINE K · 2016 to 2017
$156k
NCATS NIH HHS UL1 TR002345NHLBI NIH HHS K99 HL130339NHLBI NIH HHS R00 HL130339NHLBI NIH HHS R01 HL153523NIA NIH HHS U54 AG044170
6 · The paper itself

Abstract

Sex-related differences in respiratory modulation of sympathetic activity have been observed in rodent models of sleep apnea [intermittent hypoxia (IH)]. In light of sex disparities in the respiratory response to acute IH in humans as well as changes in respiratory modulation of muscle sympathetic nerve activity (MSNA) in clinical sleep apnea, we examined sex-related differences in respiratory modulation of MSNA following acute IH. We hypothesized that respiratory modulation of MSNA would be altered in both male and female participants after IH; however, the respiratory patterning of MSNA following IH would be sex specific. Heart rate, MSNA, and respiration were evaluated in healthy male (

Indexed as

Respiratory MechanicsAdaptation, PhysiologicalAdultBiomarkersFemaleHeart RateHumansHypoxiaLungMaleMuscle, SkeletalOxygenSex FactorsSympathetic Nervous SystemTime FactorsYoung AdultBiomarkersOxygenintermittent hypoxiamuscle sympathetic nerve activitywomen

Identifiers

PMID34668438
PMCPMC8714811

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.